UBE2G1 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 17452445)
34

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)

		UBE2G1	DIO2
Description		ubiquitin conjugating enzyme E2 G1	iodothyronine deiodinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Selenocysteine Incorporation Thyroid Hormone Generation Response To Lipopolysaccharide Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of thyroid hormone activity Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		24 interacting genes: AMFR APP CBL CRBN CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM2 TRIM63 UBA1 UBC UBE2E1 UBE3A ZRANB1	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		7326	1734
HPRD ID		03340	09027
Ensembl ID		ENSG00000132388	ENSG00000211448
Uniprot IDs		P62253	A8K845 Q92813
PDB IDs		2AWF 6D68
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Protein Polyubiquitination Macromolecule Catabolic Process Protein Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein Monoubiquitination Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin-specific Protease Binding Zinc Ion Binding Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Signal Transduction Protein Alpha-1,2-demannosylation Metal Ion Binding Protein Deglycosylation Regulation Of Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Endoplasmic Reticulum Quality Control Compartment Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Catabolic Process ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Necrotic Cell Death Regulation Of Post-translational Protein Modification Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification	Post-translational Protein Modification Protein Modification Process Protein Polyubiquitination Proteolysis Protein Ubiquitination Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity G Protein-coupled Receptor Binding ER Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Cysteine-type Deubiquitinase Activity ERAD Pathway Macromolecule Metabolic Process Protein Deubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Protein Aggregate Center Assembly Protein Catabolic Process Cysteine-type Peptidase Activity VCB Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Catabolic Process Hrd1p Ubiquitin Ligase Complex Response To Endoplasmic Reticulum Stress Negative Regulation Of Cholesterol Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Glycoprotein Metabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Ubiquitin Protein Ligase Binding Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding Regulation Of Autophagy Centrosome Duplication Protein Deglycosylation
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