UBE2G1 and DIO2

Number of citations of the paper that reports this interaction (PMID 17452445)
22

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)

		UBE2G1	DIO2
Gene Name		ubiquitin-conjugating enzyme E2G 1	deiodinase, iodothyronine, type II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AMFR APP CBL DIO2 HUWE1 ITCH MARCH6 PARK2 RBCK1 RBX1 UBA1 UBE2E1 UBE3A	6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		7326	1734
HPRD ID		03340	09027
Ensembl ID		ENSG00000132388	ENSG00000211448
Uniprot IDs		P62253	A8K845 Q92813 Q9HCP7
PDB IDs		2AWF
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Catabolic Process Protein Monoubiquitination Protein Metabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K29-linked Ubiquitination Cellular Metabolic Process Cellular Response To Stimulus Regulation Of Protein Catabolic Process Notch Signaling Pathway Negative Regulation Of JNK Cascade Protein K63-linked Ubiquitination Intracellular Receptor Signaling Pathway Viral Process Regulation Of Protein Ubiquitination Negative Regulation Of Stress-activated MAPK Cascade Histone Ubiquitination Positive Regulation Of Protein Catabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Autoubiquitination Regulation Of Signal Transduction Response To Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Learning Or Memory Cognition Positive Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Sperm Entry Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Signaling	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding
Tagcloud ?			cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Difference) ?			cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Intersection) ?