UBE2G1 and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 36481767)
76

Data Source:
BioGRID (pull down)

		UBE2G1	TRIM2
Description		ubiquitin conjugating enzyme E2 G1	tripartite motif containing 2
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)	Apolipoprotein A1 levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis ( 21654844) Thyrotoxic periodic paralysis ( 33105104)
Interacting Genes		24 interacting genes: AMFR APP CBL CRBN CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM2 TRIM63 UBA1 UBC UBE2E1 UBE3A ZRANB1	31 interacting genes: BCL2L11 CDK20 CIB3 COG3 CSNK1E DTNBP1 GJB5 KCTD7 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2C UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2H UBE2K UBE2N UBE2U UBE2W
Entrez ID		7326	23321
HPRD ID		03340	10279
Ensembl ID		ENSG00000132388	ENSG00000109654
Uniprot IDs		P62253	A0A0J9YW02 A0A6Q8PF74 A0A6Q8PG16 A0A6Q8PGG4 A0A6Q8PHP4 Q9C040
PDB IDs		2AWF 6D68	7B2R 7B96 7QRV 7ZJ3 8A38 8AMS
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Protein Polyubiquitination Macromolecule Catabolic Process Protein Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein Monoubiquitination Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin-specific Protease Binding Zinc Ion Binding Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Signal Transduction Protein Alpha-1,2-demannosylation Metal Ion Binding Protein Deglycosylation Regulation Of Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Endoplasmic Reticulum Quality Control Compartment Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Catabolic Process ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Necrotic Cell Death Regulation Of Post-translational Protein Modification Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination ATP Binding Transferase Activity Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein Catabolic Process ISG15 Transferase Activity Ubiquitin Ligase Complex ISG15-protein Conjugation Cellular Response To Stress DNA Damage Response Free Ubiquitin Chain Polymerization Catabolic Process Cytosol Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway DNA Repair Filopodium Tip Protein Binding Ubiquitin Binding Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein K6-linked Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Homeostasis DNA Metabolic Process Nucleus Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Defense Response To Virus
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