DIO2

Gene Name		deiodinase, iodothyronine, type II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		1734
HPRD ID		09027
Ensembl ID		ENSG00000211448
Uniprot IDs		A8K845 Q92813 Q9HCP7
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding
Tagcloud ?		cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb