DIO2 and MARCH6

Number of citations of the paper that reports this interaction (PMID 19651899)
20

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		DIO2	MARCH6
Gene Name		deiodinase, iodothyronine, type II	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Protein K48-linked Ubiquitination
Pathways		Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS			Body mass index ( 22446040)
Protein-Protein Interactions		6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1	3 interactors: DIO2 UBE2D2 UBE2G1
Entrez ID		1734	10299
HPRD ID		09027	11095
Ensembl ID		ENSG00000211448	ENSG00000145495
Uniprot IDs		A8K845 Q92813 Q9HCP7	O60337
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding	Protein K48-linked Ubiquitination Protein Polyubiquitination Thyroid Hormone Catabolic Process Catabolic Process Selenocysteine Incorporation Hormone Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Thyroid Hormone Generation Cellular Modified Amino Acid Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Thyroid Hormone Metabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Hormone Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Proteolysis Phenol-containing Compound Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response
Tagcloud ?		cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Difference) ?		cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb
Tagcloud (Intersection) ?