DIO2 and USP20

Number of citations of the paper that reports this interaction (PubMedID 12865408)
31

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		DIO2	USP20
Description		iodothyronine deiodinase 2	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Response To Lipopolysaccharide Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis	Proteolysis Endocytosis Canonical NF-kappaB Signal Transduction Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response
Pathways		Regulation of thyroid hormone activity Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Ub-specific processing proteases
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	71 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GPRASP3 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPAST SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB
Entrez ID		1734	10868
HPRD ID		09027	07505
Ensembl ID		ENSG00000211448	ENSG00000136878
Uniprot IDs		A8K845 Q92813	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Polyubiquitination Proteolysis Protein Ubiquitination Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity G Protein-coupled Receptor Binding ER Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Cysteine-type Deubiquitinase Activity ERAD Pathway Macromolecule Metabolic Process Protein Deubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Protein Aggregate Center Assembly Protein Catabolic Process Cysteine-type Peptidase Activity VCB Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Catabolic Process Hrd1p Ubiquitin Ligase Complex Response To Endoplasmic Reticulum Stress Negative Regulation Of Cholesterol Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Glycoprotein Metabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Ubiquitin Protein Ligase Binding Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding Regulation Of Autophagy Centrosome Duplication Protein Deglycosylation	Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Macromolecule Metabolic Process Cellular Response To Stress FFAT Motif Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleus COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Hemoglobin Biosynthetic Process Ubiquitin Protein Ligase Binding Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Endoplasmic Reticulum Localization Vesicle Budding From Membrane Cellular Response To Oxygen Levels Protein Kinase Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Intracellular Oxygen Homeostasis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Mitotic DNA Replication Checkpoint Signaling Alpha-tubulin Binding Host-mediated Activation Of Viral Genome Replication Hemoglobin Metabolic Process Peripheral Nervous System Neuron Development Negative Regulation Of Apoptotic Process Regulation Of Skeletal Muscle Adaptation Host-mediated Perturbation Of Viral Genome Replication Neuroblast Proliferation Negative Regulation Of Programmed Cell Death
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