DIO2 and USP20

Number of citations of the paper that reports this interaction (PMID 12865408)
31

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		DIO2	USP20
Gene Name		deiodinase, iodothyronine, type II	ubiquitin specific peptidase 20
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Cellular Nitrogen Compound Metabolic Process Thyroid Hormone Metabolic Process Hormone Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Endocytosis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Amine-derived hormones Regulation of thyroid hormone activity Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: MARCH6 UBE2G1 UBE2J1 USP20 USP33 WSB1	20 interactors: ALAS1 BEND5 BEND7 CCDC36 DIO2 FATE1 HIF1A MAGEA11 MDFI PJA1 PLA2G2A PRKCI RAD17 SPRY2 TRIM23 USP15 USP21 USP28 VAPB VHL
Entrez ID		1734	10868
HPRD ID		09027	07505
Ensembl ID		ENSG00000211448	ENSG00000136878
Uniprot IDs		A8K845 Q92813 Q9HCP7	Q9Y2K6
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Deubiquitination Cellular Protein Modification Process Protein K63-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Proteolysis Protein Deubiquitination Protein Modification By Small Protein Removal Catabolic Process Protein Polyubiquitination Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Metabolic Process Protein K63-linked Ubiquitination Centrosome Duplication ER-associated Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of Proteolysis Negative Regulation Of Protein Binding Centrosome Cycle Positive Regulation Of Protein Binding	Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Metabolic Process Histone Deubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Localization Within Membrane Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation By Host Of Viral Release From Host Cell Neural Fold Elevation Formation Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Membrane Budding Histone H2B Conserved C-terminal Lysine Deubiquitination Elastin Metabolic Process Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Thyroid Hormone Catabolic Process Response To Interleukin-1 Regulation Of Cell Proliferation Positive Regulation Of Cell Differentiation Regulation Of Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Stimulus Cellular Response To Decreased Oxygen Levels Positive Regulation Of Catalytic Activity Cellular Protein Modification Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Negative Regulation Of Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Establishment Of Cell Polarity Cellular Response To Oxygen Levels Response To Stimulus Protein Metabolic Process Embryonic Placenta Development
Tagcloud ?		cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Difference) ?		cga deiodinase hypothalamic hypothalamus intra intraperitoneal ko littermates mct mct8 nbr neuromedin paracrine pituitary releasing slc16a2 slight t3 t4 thrb thyroid thyroidal thyrotropin thyroxine trh trhr triiodothyronine tsh tshb	ablated adrenergic arrestin ars betaar blocker carvedilol desensitization deubiquitinases e3 endogenously flag hek interacted internalized itinerary ligase lysosomal machineries march2 proteomics recruit recycling serves stabilized ubiquitinated ubiquitination usp33 vsmcs
Tagcloud (Intersection) ?