NQO1

Description		NAD(P)H quinone dehydrogenase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Identical Protein Binding NADH Dehydrogenase (quinone) (non-electrogenic) Activity
	Biological Process	Protein Polyubiquitination Ubiquinone Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Response To Toxic Substance Removal Of Superoxide Radicals Protein Catabolic Process Response To Lipopolysaccharide Cellular Response To Oxidative Stress Negative Regulation Of Protein Catabolic Process Vitamin E Metabolic Process Vitamin K Metabolic Process Innate Immune Response Cell Redox Homeostasis Response To Caloric Restriction Negative Regulation Of Ferroptosis
Pathways		Regulation of ornithine decarboxylase (ODC) NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Novel Interacting Genes		2 novel interacting genes: CDH16 CDH5
Interacting Genes		10 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1
Entrez ID		1728
HPRD ID		00518
Ensembl ID		ENSG00000181019
Uniprot IDs		B4DLR8 P15559
PDB IDs		1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC 8C9J 8OK0 8PQN 8RFM 8RFN
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Post-translational Protein Modification Protein-folding Chaperone Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Binding Regulation Of Growth Histone Deacetylase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Cell Growth Enzyme Binding Hsp70 Protein Binding Regulation Of Mitophagy Protein-containing Complex Cellular Response To Heat Regulation Of Autophagy Of Mitochondrion Regulation Of Protein-containing Complex Assembly Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Heat Shock Protein Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Protein Stabilization Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Response To Heat
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