CD59 and NCR3

Number of citations of the paper that reports this interaction (PubMedID 14635045)
0

Data Source:
HPRD (in vitro, in vivo)

		CD59	NCR3
Description		CD59 molecule (CD59 blood group)	natural cytotoxicity triggering receptor 3
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Side Of Membrane	Plasma Membrane Membrane
	Molecular Function	Complement Binding Protein Binding Protein Sequestering Activity	Protein Binding Identical Protein Binding Immune Receptor Activity
	Biological Process	Negative Regulation Of Activation Of Membrane Attack Complex Complement Activation Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Negative Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity	Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity NK T Cell Activation
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 19079260)
Interacting Genes		16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC TMEM132D	5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G
Entrez ID		966	259197
HPRD ID		00117	11384
Ensembl ID		ENSG00000085063	ENSG00000204475
Uniprot IDs		P13987 Q6FHM9	O14931 Q05D23
PDB IDs		1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0 8B0F 8B0G 8B0H 8CN6	3NOI 3PV6 6YJP 9FWW
Enriched GO Terms of Interacting Partners?		Cell Activation Membrane Attack Complex Regulation Of Immune System Process Other Organism Cell Membrane Membrane Natural Killer Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Effector Process Activation Of Immune Response Complement Activation, GZMK Pathway Negative Regulation Of Adenylate Cyclase Activity Transmembrane Transporter Complex Complement Activation, Alternative Pathway Interleukin-6-mediated Signaling Pathway Plasma Membrane Uterus Development Leukocyte Activation Immune System Process External Side Of Plasma Membrane Negative Regulation Of Striated Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Complement Activation, Classical Pathway Cell Killing Cytotoxic T Cell Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Creatine:sodium Symporter Activity L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Macrophage Migration Regulation Of Lymphocyte Mediated Immunity Immune Response Cellular Defense Response Lymphocyte Activation Dendrite Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Complement Activation Positive Regulation Of Myeloid Dendritic Cell Activation Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis	Fc-gamma Receptor III Complex Activation Of Immune Response Positive Regulation Of Immune Response Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface T Cell Activation Positive Regulation Of Immune System Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Tertiary Granule Membrane Lymphocyte Activation IgE Receptor Activity Leukocyte Activation Alpha-beta T Cell Activation Regulation Of Immune System Process Cell Activation Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Immune System Process Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Positive Regulation Of Type III Hypersensitivity BAT3 Complex Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Maintenance Of Unfolded Protein Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Transmembrane Signaling Receptor Activity Alpha-beta T Cell Receptor Complex Complement Binding Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Internal Peptidyl-lysine Acetylation NK T Cell Activation
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