CD59 and NCR1

Number of citations of the paper that reports this interaction (PubMedID 14635045)
0

Data Source:
HPRD (in vivo)

		CD59	NCR1
Description		CD59 molecule (CD59 blood group)	natural cytotoxicity triggering receptor 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Side Of Membrane	Plasma Membrane Membrane SWI/SNF Complex
	Molecular Function	Complement Binding Protein Binding Protein Sequestering Activity	Protein Binding
	Biological Process	Negative Regulation Of Activation Of Membrane Attack Complex Complement Activation Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Negative Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity	Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)	Blood protein levels ( 30072576) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC TMEM132D	8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B
Entrez ID		966	9437
HPRD ID		00117	05167
Ensembl ID		ENSG00000085063	ENSG00000189430
Uniprot IDs		P13987 Q6FHM9	A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036
PDB IDs		1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0 8B0F 8B0G 8B0H 8CN6	1OLL 1P6F 6IAP
Enriched GO Terms of Interacting Partners?		Cell Activation Membrane Attack Complex Regulation Of Immune System Process Other Organism Cell Membrane Membrane Natural Killer Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Effector Process Activation Of Immune Response Complement Activation, GZMK Pathway Negative Regulation Of Adenylate Cyclase Activity Transmembrane Transporter Complex Complement Activation, Alternative Pathway Interleukin-6-mediated Signaling Pathway Plasma Membrane Uterus Development Leukocyte Activation Immune System Process External Side Of Plasma Membrane Negative Regulation Of Striated Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Complement Activation, Classical Pathway Cell Killing Cytotoxic T Cell Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Creatine:sodium Symporter Activity L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Macrophage Migration Regulation Of Lymphocyte Mediated Immunity Immune Response Cellular Defense Response Lymphocyte Activation Dendrite Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Complement Activation Positive Regulation Of Myeloid Dendritic Cell Activation Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis	Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Leukocyte Activation Cell Activation Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding External Side Of Plasma Membrane Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Fc Receptor Signaling Pathway Tertiary Granule Membrane IgE Receptor Activity Acetylcholine Receptor Activator Activity Positive Regulation Of Immune System Process PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Membrane Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Immune System Process Activation Of Immune Response Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet
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