C9 and CD59

Number of citations of the paper that reports this interaction (PMID 1377690)
15

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		C9	CD59
Gene Name		complement component 9	CD59 molecule, complement regulatory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Vesicle Sarcolemma Compact Myelin Extracellular Vesicular Exosome
	Molecular Function		Complement Binding Protein Binding
	Biological Process	Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Hemolysis By Symbiont Of Host Erythrocytes Regulation Of Complement Activation Innate Immune Response	Cell Activation Negative Regulation Of Activation Of Membrane Attack Complex Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146)
Protein-Protein Interactions		3 interactors: C8A CD59 CLU	12 interactors: C8A C9 CD2 CD8A CD9 EGFR GNAI3 NCR1 NCR3 SLC6A8 SMAD4 SRC
Entrez ID		735	966
HPRD ID		00408	00117
Ensembl ID		ENSG00000113600
Uniprot IDs		P02748	E9PI80 P13987 Q6FHM9
PDB IDs			1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Negative Regulation Of Activation Of Membrane Attack Complex Protein Activation Cascade Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Positive Regulation Of Neurofibrillary Tangle Assembly Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Regulation Of Protein Metabolic Process Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Complement Activation, Alternative Pathway Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Complement Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Body Fluid Levels Glial Cell Proliferation Wound Healing Response To Misfolded Protein Regulation Of Beta-amyloid Formation Positive Regulation Of Immune Response Regulation Of Inclusion Body Assembly	Cell Activation Response To Stress Regulation Of Immune System Process Regulation Of Immune Response Defense Response Immune System Process Complement Activation, Alternative Pathway Positive Regulation Of Protein Transport Immune Response Membrane Organization Blood Coagulation Hemostasis Positive Regulation Of Immune System Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Cytolysis Single Organismal Cell-cell Adhesion Platelet Activation Regulation Of Complement Activation Regulation Of Body Fluid Levels Wound Healing Cell Adhesion Regulation Of Protein Transport Positive Regulation Of Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Establishment Of Protein Localization Leukocyte Mediated Immunity Adaptive Immune Response Response To Wounding Regulation Of Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transport Natural Killer Cell Activation Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Innate Immune Response Alkanesulfonate Metabolic Process Cytotoxic T Cell Differentiation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Myeloid Dendritic Cell Activation Regulation Of Acute Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Positive Regulation Of Cytokine Secretion Regulation Of Protein Processing Positive Regulation Of Protein Import Into Nucleus Lymphocyte Activation
Tagcloud ?		astroglial axotomy bromodeoxyuridine c3d complement degeneration degenerative enables gfap glial hypoglossal immunoreactivity injured ipsilateral massive microglial motorneuron nerve oligodendroglial ox42 phagocytosis principally profound rca ricin situation somata transection transferrin	activation attack axotomy cause clusterin complement contribute death degeneration facial following homologous hybridization immunocytochemistry intracranial massive motor nerve neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ transection
Tagcloud (Difference) ?		astroglial bromodeoxyuridine c3d degenerative enables gfap glial hypoglossal immunoreactivity injured ipsilateral microglial motorneuron oligodendroglial ox42 phagocytosis principally profound rca ricin situation somata transferrin	activation attack cause clusterin contribute death facial following homologous hybridization immunocytochemistry intracranial motor neuronal neurons neuroprotective nucleus propose proposed regulators show shown situ
Tagcloud (Intersection) ?		axotomy complement degeneration massive nerve transection