C9 and CD59

Number of citations of the paper that reports this interaction (PubMedID 7523406)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		C9	CD59
Description		complement C9	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Side Of Membrane
	Molecular Function	Protein Binding	Complement Binding Protein Binding Protein Sequestering Activity
	Biological Process	Cell Killing Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Protein Homooligomerization Complement Activation, GZMK Pathway	Negative Regulation Of Activation Of Membrane Attack Complex Complement Activation Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Negative Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity
Pathways		Terminal pathway of complement Regulation of Complement cascade	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs		Copper
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) Health literacy ( 31250787) Systemic lupus erythematosus ( 19838195)	Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		4 interacting genes: C8A CD59 CLU LAMTOR5	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC TMEM132D
Entrez ID		735	966
HPRD ID		00408	00117
Ensembl ID		ENSG00000113600	ENSG00000085063
Uniprot IDs		P02748	P13987 Q6FHM9
PDB IDs		5FMW 6DLW 6H03 6H04 7NYC 7NYD 8B0G 8B0H 8DE6	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY 6ZD0 8B0F 8B0G 8B0H 8CN6
Enriched GO Terms of Interacting Partners?		Complement Activation Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Complement-dependent Cytotoxicity Complement Binding Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Regulation Of Complement Activation Humoral Immune Response Complement Activation, Classical Pathway Protein Sequestering Activity Immune Effector Process Regulation Of Humoral Immune Response Activation Of Immune Response Protein Localization To Lysosome Protein Localization To Vacuole Positive Regulation Of Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Blood Microparticle Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Immune Response Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Immune System Process Negative Regulation Of Immune Response Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Response To Other Organism Positive Regulation Of Inclusion Body Assembly Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Ragulator Complex Immune Response Regulation Of Neurofibrillary Tangle Assembly Membrane Attack Complex Other Organism Cell Membrane Protein Import Response To External Biotic Stimulus Spherical High-density Lipoprotein Particle FNIP-folliculin RagC/D GAP Microglial Cell Proliferation Extracellular Space Protein Carrier Chaperone Protein-containing Complex Binding Complement Activation, GZMK Pathway Regulation Of Immune System Process Transmembrane Transporter Complex Response To Virus Response To Misfolded Protein Negative Regulation Of Amyloid Fibril Formation	Cell Activation Membrane Attack Complex Regulation Of Immune System Process Other Organism Cell Membrane Membrane Natural Killer Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Effector Process Activation Of Immune Response Complement Activation, GZMK Pathway Negative Regulation Of Adenylate Cyclase Activity Transmembrane Transporter Complex Complement Activation, Alternative Pathway Interleukin-6-mediated Signaling Pathway Plasma Membrane Uterus Development Leukocyte Activation Immune System Process External Side Of Plasma Membrane Negative Regulation Of Striated Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Complement Activation, Classical Pathway Cell Killing Cytotoxic T Cell Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Creatine:sodium Symporter Activity L-cysteine-S-conjugate N-acetyltransferase Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Macrophage Migration Regulation Of Lymphocyte Mediated Immunity Immune Response Cellular Defense Response Lymphocyte Activation Dendrite Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Complement Activation Positive Regulation Of Myeloid Dendritic Cell Activation Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis
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