TREM1

Description		triggering receptor expressed on myeloid cells 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Activity Scaffold Protein Binding Receptor Decoy Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Humoral Immune Response Neutrophil Chemotaxis Intracellular Signal Transduction Innate Immune Response Neutrophil-mediated Killing Of Gram-negative Bacterium
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall DAP12 interactions
Drugs		D-tartaric acid
Diseases
GWAS		Blood protein levels ( 30072576) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		1 interacting genes: TYROBP
Entrez ID		54210
HPRD ID		05472
Ensembl ID		ENSG00000124731
Uniprot IDs		K7EKM5 Q38L15 Q9NP99
PDB IDs		1Q8M 1SMO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoclast Development Microglial Cell Activation Involved In Immune Response Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Transforming Growth Factor Beta1 Production T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Osteoclast Development Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of B Cell Proliferation Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Interleukin-10 Production Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Microglial Cell Activation Cellular Response To Lectin Regulation Of Receptor Localization To Synapse Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Activation Regulation Of Superoxide Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Amyloid-beta Clearance Apoptotic Cell Clearance Neutrophil Activation Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of B Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Protein Localization To Cell Surface Regulation Of Long-term Synaptic Potentiation Regulation Of Natural Killer Cell Activation Semaphorin-plexin Signaling Pathway Natural Killer Cell Mediated Immunity Negative Regulation Of Type I Interferon Production Osteoclast Differentiation Cellular Response To Amyloid-beta Cellular Defense Response Response To Axon Injury Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of B Cell Proliferation Macrophage Activation Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Response To Amyloid-beta Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity T Cell Activation Involved In Immune Response
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