TREM1 and TYROBP

Number of citations of the paper that reports this interaction (PMID 10799849)
126

Data Source:
HPRD (in vivo)

		TREM1	TYROBP
Gene Name		triggering receptor expressed on myeloid cells 1	TYRO protein tyrosine kinase binding protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Receptor Activity Scaffold Protein Binding	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Cytokine Secretion Involved In Immune Response Humoral Immune Response Blood Coagulation Neutrophil Chemotaxis Intracellular Signal Transduction Innate Immune Response Chemokine Metabolic Process Leukocyte Migration Neutrophil Mediated Killing Of Gram-negative Bacterium Neutrophil Extravasation	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development
Pathways		DAP12 interactions Cell surface interactions at the vascular wall Innate Immune System	DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs		D-tartaric acid
Diseases
GWAS
Protein-Protein Interactions		1 interactors: TYROBP	13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70
Entrez ID		54210	7305
HPRD ID		05472	04996
Ensembl ID		ENSG00000124731	ENSG00000011600
Uniprot IDs		K7EJW1 Q38L15 Q9NP99	O43914
PDB IDs		1Q8M 1SMO	2L34 2L35
Enriched GO Terms of Interacting Partners?		Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Macrophage Activation Cellular Defense Response Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Integrin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation	Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation
Tagcloud ?		1x10 3x10 6x10 7x10 9x10 aging cohorts copyright cytometric decline endophenotypes gwas intronic neuritic neurofibrillary neuropathological plaques pursue reserved rights rs6910730g rs7759295c tangle tangles trem2 treml2 triggering variants	acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering
Tagcloud (Difference) ?		1x10 3x10 6x10 7x10 9x10 aging cohorts copyright cytometric decline endophenotypes gwas intronic neuritic neurofibrillary neuropathological plaques pursue reserved rights rs6910730g rs7759295c tangle tangles treml2 variants	acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate
Tagcloud (Intersection) ?		trem2 triggering