TREM2

Gene Name		triggering receptor expressed on myeloid cells 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lipopolysaccharide Binding Receptor Activity Peptidoglycan Binding Lipoteichoic Acid Binding Scaffold Protein Binding
	Biological Process	Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Humoral Immune Response Axon Guidance Detection Of Lipopolysaccharide Detection Of Peptidoglycan Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Dendritic Cell Differentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of CD40 Signaling Pathway
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Innate Immune System
Drugs
Diseases
GWAS		C-reactive protein ( 22939635)
Protein-protein Interactions		1 interactors: TYROBP
Entrez ID		54209
HPRD ID		05473
Ensembl ID		ENSG00000095970
Uniprot IDs		Q5TCX1 Q9NZC2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Macrophage Activation Cellular Defense Response Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Integrin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation
Tagcloud ?		apoe4 apparatus arginine cysts detailed differs glycosylated glycosylation golgi gwas hakola histidine impaired modulatory mutated nasu nhd oligosaccharides phagocytosis polymorphism precise q33x r47h secretase snp t66m trafficking triggering y38c