TREM2 and TYROBP

Number of citations of the paper that reports this interaction (PubMedID 12080485)
34

Data Source:
HPRD (in vivo)

		TREM2	TYROBP
Description		triggering receptor expressed on myeloid cells 2	transmembrane immune signaling adaptor TYROBP
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Plasma Membrane Raft	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Protein Binding Phospholipid Binding Beta-catenin Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Semaphorin Receptor Activity Kinase Activator Activity Low-density Lipoprotein Particle Binding Semaphorin Receptor Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Carbohydrate Derivative Binding Sulfatide Binding Protein Tyrosine Kinase Binding	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Microglial Cell Activation Microglial Cell Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Inflammatory Response To Antigenic Stimulus Response To Ischemia Phagocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Humoral Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Memory Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Negative Regulation Of Triglyceride Storage Positive Regulation Of High-density Lipoprotein Particle Clearance Regulation Of Lipid Metabolic Process Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 6 Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Glial Cell Apoptotic Process Social Behavior CXCL12-activated CXCR4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Potassium Ion Transport Apoptotic Cell Clearance Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Respiratory Burst After Phagocytosis Positive Regulation Of Complement Activation, Classical Pathway Astrocyte Activation Cell Development Response To Axon Injury Positive Regulation Of Protein Secretion Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lipid Homeostasis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Negative Regulation Of Astrocyte Activation Regulation Of Biological Quality Pyroptotic Inflammatory Response Negative Regulation Of Fat Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Glucose Stimulus Cellular Response To Lipid Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Hypoxia Semaphorin-plexin Signaling Pathway Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Dendritic Spine Maintenance Amyloid-beta Clearance Import Into Cell Regulation Of Hippocampal Neuron Apoptotic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Complement-mediated Synapse Pruning Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Amyloid-beta Clearance By Cellular Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of P38MAPK Cascade Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Low-density Lipoprotein Particle Clearance Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Cytokine Production Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Immune Effector Process Myeloid Leukocyte Activation Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immune System Process Positive Regulation Of Immune System Process Defense Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Regulation Of Biological Quality Semaphorin-plexin Signaling Pathway Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Cell Surface Regulation Of Osteoclast Development Positive Regulation Of Osteoclast Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)
Interacting Genes		10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B	15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70
Entrez ID		54209	7305
HPRD ID		05473	04996
Ensembl ID		ENSG00000095970	ENSG00000011600
Uniprot IDs		Q5TCX1 Q9NZC2	O43914 X6RGC9
PDB IDs		5ELI 5UD7 5UD8 6B8O 6XDS 6Y6C 6YMQ 6YYE 6Z0G 6Z0H 6Z0I 8T51 8T59	2L34 2L35 4WO1 4WOL 7Q5W
Enriched GO Terms of Interacting Partners?		Chylomicron Cellular Response To Amyloid-beta Response To Amyloid-beta Reverse Cholesterol Transport Cholesterol Transport Very-low-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Sterol Transport Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling High-density Lipoprotein Particle Clearance Receptor Ligand Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Endocytosis High-density Lipoprotein Particle Assembly Organic Hydroxy Compound Transport Phospholipid Efflux Low-density Lipoprotein Particle Low-density Lipoprotein Particle Remodeling Extracellular Space Endocytic Vesicle Lumen Sterol Homeostasis High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis High-density Lipoprotein Particle Chylomicron Remnant Positive Regulation Of Neurofibrillary Tangle Assembly Low-density Lipoprotein Particle Receptor Binding Cholesterol Metabolic Process Lipid Transport Regulation Of Endocytosis Phospholipid Binding Blood Microparticle Sterol Metabolic Process Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Lipid Homeostasis Extracellular Region Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Transmembrane Signaling Receptor Activity Regulation Of Immune Response Immune System Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Membrane Regulation Of Innate Immune Response Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Beta Selection Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Cellular Defense Response Regulation Of Cell Activation Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Response Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Calcium-mediated Signaling Regulation Of Natural Killer Cell Mediated Immunity Plasma Membrane Activation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Innate Immune Response Positive Regulation Of Cell Killing Immune Response Scaffold Protein Binding Positive Regulation Of Defense Response Lymphocyte Activation Regulation Of Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Defense Response Regulation Of Calcium-mediated Signaling Signaling Receptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phagocytosis Adaptive Immune Response
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