TYMS and SH3GL2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TYMS	SH3GL2
Gene Name		thymidylate synthetase	SH3-domain GRB2-like 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding MRNA Binding Thymidylate Synthase Activity Folic Acid Binding Drug Binding Protein Homodimerization Activity Cofactor Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Deoxyribonucleoside Monophosphate Biosynthetic Process Response To Toxic Substance Immortalization Of Host Cell By Virus Uracil Metabolic Process Organ Regeneration Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Response To Drug Small Molecule Metabolic Process Response To Ethanol DUMP Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Tetrahydrofolate Metabolic Process Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Nucleobase-containing Small Molecule Metabolic Process Intestinal Epithelial Cell Maturation	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways		E2F mediated regulation of DNA replication Pyrimidine biosynthesis G1/S Transition G1/S-Specific Transcription Pyrimidine metabolism Metabolism of nucleotides Mitotic G1-G1/S phases Cell Cycle, Mitotic	Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs		Raltitrexed Floxuridine Trifluridine Trimethoprim Gemcitabine Fluorouracil Pemetrexed Leucovorin Capecitabine Thymidine-5\'-Phosphate 10-Propargyl-5,8-Dideazafolic Acid 2\'-deoxyuridylic acid S,S-(2-Hydroxyethyl)Thiocysteine Pralatrexate 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE
Diseases
GWAS			Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		2 interactors: SH3GL2 UPF2	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		7298	6456
HPRD ID		01774	05125
Ensembl ID		ENSG00000176890	ENSG00000107295
Uniprot IDs		P04818 Q53Y97	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs		1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?			Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights shmt1 slc19a1 snps	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?		aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights shmt1 slc19a1 snps	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?