TYMS

Description		thymidylate synthetase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Thymidylate Synthase Activity Folic Acid Binding Methyltransferase Activity Transferase Activity Transferase Activity, Transferring One-carbon Groups Sequence-specific MRNA Binding
	Biological Process	DTMP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Translation Methylation Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process DNA Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription
Drugs		Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Leukocyte telomere length ( 31171785 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)
Novel Interacting Genes		9 novel interacting genes: EPB41L3 ITGAM NAPG NDUFV2 OCRL SMCHD1 TAF3 THOC1 YES1
Interacting Genes		3 interacting genes: CDC42 SH3GL2 UPF2
Entrez ID		7298
HPRD ID		01774
Ensembl ID		ENSG00000176890
Uniprot IDs		P04818 Q53Y97
PDB IDs		1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E 6ZXO
Enriched GO Terms of Interacting Partners?		Membrane Organization
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