SH2D2A and ITK

Number of citations of the paper that reports this interaction (PubMedID 10587356)
50

Data Source:
HPRD (two hybrid)

		SH2D2A	ITK
Description		SH2 domain containing 2A	IL2 inducible T cell kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Binding SH3 Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation	Positive Regulation Of Cytokine Production NK T Cell Differentiation Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Intracellular Signal Transduction T Cell Activation Gamma-delta T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		VEGFA-VEGFR2 Pathway	Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Staurosporine Pazopanib Fostamatinib Zanubrutinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Sjögren's syndrome ( 28076899)	Asthma ( 31959851 34103634) Daytime sleep phenotypes ( 27126917) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1	34 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FGFR1 FYN GAB1 GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 MET PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS
Entrez ID		9047	3702
HPRD ID		05152	01746
Ensembl ID		ENSG00000027869	ENSG00000113263
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	Q08881
PDB IDs			1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Activation Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Signal Transduction Phospholipase Binding ERBB Signaling Pathway Regulation Of Apoptotic Process Immune System Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Intracellular Signaling Cassette Leukocyte Activation Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Kinase Activity Regulation Of Immune Response Regulation Of MAPK Cascade Membrane Raft Positive Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Binding
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