TWIST1 and KAT2B

Number of citations of the paper that reports this interaction (PubMedID 10025406)
0

Data Source:
HPRD (in vitro, in vivo)

		TWIST1	KAT2B
Description		twist family bHLH transcription factor 1	lysine acetyltransferase 2B
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Histone Acetyltransferase Complex SAGA Complex Kinetochore Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton A Band I Band Protein-containing Complex Actomyosin Mitotic Spindle ATAC Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Diamine N-acetyltransferase Activity Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Enzyme Activator Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Stem Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Energy Homeostasis Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Heart Development Memory Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Vasodilation Regulation Of RNA Splicing Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Fatty Acid Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Regulation Of Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Limb Development Regulation Of Small Molecule Metabolic Process Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Ferroptosis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of RRNA Processing
Pathways		Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm
Drugs			Coenzyme A (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 29403010 30487518 27841878 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)	Drug abuse ( 26202629) High light scatter reticulocyte count ( 32888494) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic disc size ( 31809533) Post-traumatic stress disorder ( 24677629) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Systolic blood pressure ( 30578418 30224653)
Interacting Genes		30 interacting genes: BCL6 CHD4 EP300 FBXO45 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MUC1 MYOD1 NEIL3 PTEN RBBP7 RELA SPOP STAT3 TCF3 TCF4 TP53 TRIB3 TRIM28 USP13 USP18 YY1 YY2 ZIC3 ZRANB1	128 interacting genes: ACTN1 ACTN2 AKT1 AR ARHGDIA ATF4 ATXN3 BMAL1 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 EZH2 GATAD2A GATAD2B H1-1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4C1 H4C16 HIPK2 HMGA1 HMGA2 HMGN2 HNF1A HNRNPU HOXB9 HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 LIN28B MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 N4BP3 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBM8A RBPJ RELA RPA1 RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERPINH1 SERTAD1 SERTAD2 SIRT2 SIRT7 SMAD1 SMAD2 SMAD3 SNCA SP1 SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TRIM14 TTF1 TWIST1 UBE2D1 UBE2D2 UBE2D3 XRCC6 YY1
Entrez ID		7291	8850
HPRD ID		03374	06780
Ensembl ID		ENSG00000122691	ENSG00000114166
Uniprot IDs		Q15672	Q92831
PDB IDs		2MJV 8OSB	1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3 4NSQ 5FDZ 5FE0 5FE1 5FE2 5FE3 5FE4 5FE5 5FE6 5FE7 5FE8 5FE9 5LVQ 5LVR 5MKX 6J3O
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Response To Stress Regulation Of Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of Cellular Response To Stress Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin DNA Binding DNA Damage Response	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Positive Regulation Of Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Transcription Regulator Complex DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Protein-containing Complex DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Regulation Of Developmental Process Intracellular Signal Transduction
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