TWIST1 and TCF3

Number of citations of the paper that reports this interaction (PMID 10749989)
18

Data Source:
HPRD (two hybrid)

		TWIST1	TCF3
Gene Name		twist family bHLH transcription factor 1	transcription factor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Protein Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Histone Phosphorylation Negative Regulation Of Histone Acetylation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Cell Motility Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cellular Senescence Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination Response To Drug Muscle Cell Differentiation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Peyer's Patch Development Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CHD4 EP300 GLI3 HOXA5 KAT2B MYOD1 RBBP7 RELA SETD8 TCF3	62 interactors: AEBP1 ASCL3 BHLHA15 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DAXX ELK3 EP300 FERD3L HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MAX MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NHLH1 PDX1 PRKACA PSMD4 PSMD9 RALGAPA1 RPL37 RUFY1 RUNX1T1 SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1 VDR
Entrez ID		7291	6929
HPRD ID		03374	00918
Ensembl ID		ENSG00000122691	ENSG00000071564
Uniprot IDs		Q15672	P15923 Q2TB39
PDB IDs			1HLH 2YPA 2YPB 3U5V
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Chromatin Modification RNA Metabolic Process Chromatin Organization Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Internal Protein Amino Acid Acetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Metabolic Process Response To Lipid Positive Regulation Of Cell Differentiation	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organ Development Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Anatomical Structure Development Multicellular Organismal Development Developmental Process Embryo Development Tissue Development Organ Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Embryonic Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Embryonic Organ Development
Tagcloud ?		abilities ablation benign carcinogenesis concomitant conditional csc defective defects deletion dosage emt functionally importantly independently inducing initiation maintenance manner mesenchymal promotes propagation required rescues reveal skin stemness transition unclear	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Difference) ?		abilities ablation benign carcinogenesis concomitant conditional csc defective defects deletion dosage emt functionally importantly independently inducing initiation maintenance manner mesenchymal promotes propagation required rescues reveal skin stemness transition unclear	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate prkd3 profiled profiling proteomics regard runx1 runx2 satb2 testis yap1
Tagcloud (Intersection) ?