TWIST1 and KMT5A

Number of citations of the paper that reports this interaction (PubMedID 21983900)
63

Data Source:
BioGRID (pull down)

		TWIST1	KMT5A
Description		twist family bHLH transcription factor 1	lysine methyltransferase 5A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Chromosome Polytene Chromosome Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding	Transcription Corepressor Activity Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Stem Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Energy Homeostasis Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Mitotic Chromosome Condensation Peptidyl-lysine Monomethylation Replication Fork Processing Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Cell Division Protein Localization To Chromatin Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription	Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 29403010 30487518 27841878 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		30 interacting genes: BCL6 CHD4 EP300 FBXO45 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MUC1 MYOD1 NEIL3 PTEN RBBP7 RELA SPOP STAT3 TCF3 TCF4 TP53 TRIB3 TRIM28 USP13 USP18 YY1 YY2 ZIC3 ZRANB1	14 interacting genes: BTRC DTL E2F2 FAM9A H4C1 H4C16 PCNA RNF168 RNF8 TCF7L2 TP53 TWIST1 UBE2I USP17L2
Entrez ID		7291	387893
HPRD ID		03374	06254
Ensembl ID		ENSG00000122691	ENSG00000183955
Uniprot IDs		Q15672	E3VVS3 Q9NQR1
PDB IDs		2MJV 8OSB	1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ 7D1Z 7D20 7XPX
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Response To Stress Regulation Of Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of Cellular Response To Stress Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin DNA Binding DNA Damage Response	Nucleoplasm Nucleus Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Chromosome Organization Signal Transduction In Response To DNA Damage Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region DNA Metabolic Process Negative Regulation Of Biosynthetic Process Response To Radiation Regulation Of DNA Repair Chromatin Organization Post-translational Protein Modification Protein K63-linked Ubiquitination Regulation Of DNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Site Of Double-strand Break DNA Damage Checkpoint Signaling Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Localization To Chromosome PML Body CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Chromatin Remodeling Lymphocyte Activation Involved In Immune Response Telomere Organization Proteolysis Involved In Protein Catabolic Process Regulation Of Primary Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA Repair Translesion Synthesis Synaptonemal Complex
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