TWIST1 and RBBP7

Number of citations of the paper that reports this interaction (PMID 20714342)
25

Data Source:
BioGRID (pull down)

		TWIST1	RBBP7
Gene Name		twist family bHLH transcription factor 1	retinoblastoma binding protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm NuRD Complex ESC/E(Z) Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity E-box Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Histone Phosphorylation Negative Regulation Of Histone Acetylation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Cell Motility Negative Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cellular Senescence Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Replication Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Multicellular Organismal Development Cell Proliferation Gene Expression Negative Regulation Of Cell Growth CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Cellular Heat Acclimation
Pathways			Chromosome Maintenance HDACs deacetylate histones Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Epigenetic regulation of gene expression Cellular Senescence HATs acetylate histones PRC2 methylates histones and DNA RMTs methylate histone arginines Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CHD4 EP300 GLI3 HOXA5 KAT2B MYOD1 RBBP7 RELA SETD8 TCF3	28 interactors: APPL1 APPL2 BCL11B BRCA1 BRMS1 BRMS1L CHD4 CREBBP DHX30 ESR1 GATAD2B HDAC1 HDAC2 HIST3H3 ING1 LINC00152 MBD3 MBD3L2 MTA2 NR2E3 RB1 RBBP4 RBP1 SALL2 SAP30 SIN3A SUV39H1 TWIST1
Entrez ID		7291	5931
HPRD ID		03374	04231
Ensembl ID		ENSG00000122691	ENSG00000102054
Uniprot IDs		Q15672	E9PC52 Q16576 Q6FHQ0
PDB IDs			3CFS 3CFV
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Chromatin Modification RNA Metabolic Process Chromatin Organization Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Internal Protein Amino Acid Acetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Metabolic Process Response To Lipid Positive Regulation Of Cell Differentiation	Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Remodeling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cellular Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Histone Modification Regulation Of Gene Expression Organelle Organization Macromolecule Biosynthetic Process Histone Deacetylation Protein Deacetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Histone H3-K9 Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Eyelid Development In Camera-type Eye Tissue Development Negative Regulation Of Histone Acetylation
Tagcloud ?		abilities ablation benign carcinogenesis concomitant conditional csc defective defects deletion dosage emt functionally importantly independently inducing initiation maintenance manner mesenchymal promotes propagation required rescues reveal skin stemness transition unclear	accessibility acetyltransferase alanine applicable bait code govern h3s10 hat1 mimic nonhydrolyzable outlined partners phosphonomethylen pma posttranslational ptms pull recruit retinoblastoma s10 scheme silac studying tail tails threonine uncovered unmodified
Tagcloud (Difference) ?		abilities ablation benign carcinogenesis concomitant conditional csc defective defects deletion dosage emt functionally importantly independently inducing initiation maintenance manner mesenchymal promotes propagation required rescues reveal skin stemness transition unclear	accessibility acetyltransferase alanine applicable bait code govern h3s10 hat1 mimic nonhydrolyzable outlined partners phosphonomethylen pma posttranslational ptms pull recruit retinoblastoma s10 scheme silac studying tail tails threonine uncovered unmodified
Tagcloud (Intersection) ?