TWIST1 and FBXO45

Number of citations of the paper that reports this interaction (PubMedID 25460509)
64

Data Source:
BioGRID (pull down)

		TWIST1	FBXO45
Description		twist family bHLH transcription factor 1	F-box protein 45
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane SCF Ubiquitin Ligase Complex Presynaptic Membrane Cell Projection Organelle Synapse Postsynaptic Membrane Presynapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Neural Tube Closure Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Positive Regulation Of Fatty Acid Beta-oxidation Developmental Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Outer Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of Skeletal Muscle Tissue Development Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Stem Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cranial Suture Morphogenesis Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cellular Response To Hypoxia Positive Regulation Of Monocyte Chemotactic Protein-1 Production Energy Homeostasis Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation	Neuron Migration Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nervous System Development Protein Ubiquitination Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Corticospinal Tract Morphogenesis Anterior Commissure Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innervation Synapse Assembly Involved In Innervation Axon Development Protein K48-linked Ubiquitination Regulation Of Synaptic Vesicle Exocytosis
Pathways		Interleukin-4 and Interleukin-13 signaling Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Coronary artery disease ( 33020668 32469254) Diastolic blood pressure ( 30578418) Diisocyanate-induced asthma ( 25918132) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Male-pattern baldness ( 29146897) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 29403010 30487518 27841878 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Type 2 diabetes (age of onset) ( 28060188)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851 34103634) Multiple sclerosis ( 31604244) Vitiligo ( 27723757)
Interacting Genes		30 interacting genes: BCL6 CHD4 EP300 FBXO45 GLI3 HOXA5 IKBKB KAT2B KMT5A KPNA5 KPNA7 MUC1 MYOD1 NEIL3 PTEN RBBP7 RELA SPOP STAT3 TCF3 TCF4 TP53 TRIB3 TRIM28 USP13 USP18 YY1 YY2 ZIC3 ZRANB1	8 interacting genes: FBXW7 PRNP RBX1 SNAI1 SNAI2 TP73 TWIST1 ZEB2
Entrez ID		7291	200933
HPRD ID		03374	19508
Ensembl ID		ENSG00000122691	ENSG00000174013
Uniprot IDs		Q15672	P0C2W1
PDB IDs		2MJV 8OSB
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Chromatin Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Response To Stress Regulation Of Metabolic Process Chromatin Organization Chromatin Remodeling Regulation Of Cellular Response To Stress Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin DNA Binding DNA Damage Response	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Ameboidal-type Cell Migration Epithelial Cell Migration Aortic Valve Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Cellular Response To Stress Heart Valve Morphogenesis Regulation Of Intracellular Signal Transduction E-box Binding Regulation Of Cell Communication Regulation Of RNA Metabolic Process Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Cartilage Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Vitamin Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Lipid Metabolic Process Mesenchymal Cell Differentiation Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Osteoblast Differentiation
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