TULP3 and TNNT3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TULP3	TNNT3
Description		TUB like protein 3	troponin T3, fast skeletal type
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cilium Axoneme Membrane Ciliary Basal Body Cell Projection Ciliary Base 9+0 Non-motile Cilium	Cytosol Troponin Complex
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Phosphatidylinositol Binding Protein-containing Complex Binding Intraciliary Transport Particle A Binding	Actin Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Calcium-dependent Protein Binding
	Biological Process	Neural Tube Formation Neural Tube Closure Regulation Of DNA-templated Transcription G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Anterior/posterior Pattern Specification Dorsal/ventral Neural Tube Patterning Neural Tube Development Central Nervous System Neuron Differentiation Embryonic Camera-type Eye Development Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Limb Development Bone Development Bronchus Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Localization To Cilium Ganglion Development	Skeletal Muscle Contraction Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of ATP-dependent Activity Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity
Pathways		Hedgehog 'off' state	Striated Muscle Contraction
Drugs
Diseases			Distal arthrogryposis (DA)
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Appendicular lean mass ( 33097823) Celiac disease ( 23936387) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 30487518) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 27618448 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		61 interacting genes: ACTN2 AKAP9 ANKRD1 ARHGAP21 ARMCX2 ATP2A1 BACH2 BOC BRMS1L BTBD1 CCNB1 CHD2 CLIP4 DNTTIP2 DROSHA DST ESRRG GPATCH2L GSE1 HSF2BP KIF3A KLF10 KRTAP10-1 KRTAP10-5 KRTAP10-7 MAGEA6 MAP3K5 MBTD1 MGA MORF4L1 MYBPC2 MYH3 MYH7 MYO18B NCOR1 NFE2L1 NOSTRIN NRIP1 PAF1 PCGF6 PDE4DIP PHAX PSTPIP1 RCOR3 RIOK3 RNF10 ROPN1 RYR1 SLAIN2 SPTB SRP72 TNNT1 TNNT3 WNK1 ZFAT ZNF160 ZNF462 ZNF619 ZNF793 ZNF835 ZSCAN23	10 interacting genes: CLIP4 HAP1 NLGN3 NUDT3 SNUPN TNNI2 TRIM63 TSG101 TULP3 WASL
Entrez ID		7289	7140
HPRD ID		05292	02822
Ensembl ID		ENSG00000078246	ENSG00000130595
Uniprot IDs		B7Z1E7 O75386	A0A286YFB1 A0A9L9PY19 H9KVA2 P45378
PDB IDs		8FH3
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Actomyosin Structure Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Myosin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Skeletal Muscle Contraction Actin Filament-based Process H Zone Striated Muscle Contraction Myofibril Actin Cytoskeleton Organization Sarcomere Actin Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Microtubule Plus-end Myosin II Complex Organelle Organization I Band Histone Deacetylase Binding Z Disc Extrinsic Component Of Postsynaptic Density Membrane Striated Muscle Cell Development Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization DNA Binding Transition Between Fast And Slow Fiber Muscle System Process Negative Regulation Of RNA Metabolic Process Troponin Complex Cardiac Muscle Cell Development Muscle Cell Development Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Regulation Of Primary Metabolic Process Cardiac Cell Development Microtubule-based Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Adaptation Myosin Complex Actin Filament Binding	Vesicle Localization Establishment Of Vesicle Localization Nucleus Positive Regulation Of Cellular Component Biogenesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Viral Budding Via Host ESCRT Complex Intraciliary Transport Particle A Binding Bronchus Morphogenesis Negative Regulation Of Membrane Tubulation Vesicle Cytoskeletal Trafficking Positive Regulation Of Clathrin-dependent Endocytosis Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Neurotrophin Production Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity SnRNA Import Into Nucleus 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Rhythmic Synaptic Transmission Symmetric, GABA-ergic, Inhibitory Synapse Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Troponin T Binding Exosomal Secretion Organelle Localization Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Actin Cap RNA Import Into Nucleus Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Asymmetric, Glutamatergic, Excitatory Synapse Positive Regulation Of Cellular Component Organization Hypothalamus Cell Differentiation Skeletal Muscle Atrophy
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