TULP3 and NOSTRIN

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TULP3	NOSTRIN
Description		TUB like protein 3	nitric oxide synthase trafficking
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cilium Axoneme Membrane Ciliary Basal Body Cell Projection Ciliary Base 9+0 Non-motile Cilium	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Phosphatidylinositol Binding Protein-containing Complex Binding Intraciliary Transport Particle A Binding	DNA Binding Protein Binding
	Biological Process	Neural Tube Formation Neural Tube Closure Regulation Of DNA-templated Transcription G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Anterior/posterior Pattern Specification Dorsal/ventral Neural Tube Patterning Neural Tube Development Central Nervous System Neuron Differentiation Embryonic Camera-type Eye Development Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Embryonic Neurocranium Morphogenesis Limb Development Bone Development Bronchus Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Localization To Cilium Ganglion Development	Endocytosis Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways		Hedgehog 'off' state	NOSTRIN mediated eNOS trafficking
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		61 interacting genes: ACTN2 AKAP9 ANKRD1 ARHGAP21 ARMCX2 ATP2A1 BACH2 BOC BRMS1L BTBD1 CCNB1 CHD2 CLIP4 DNTTIP2 DROSHA DST ESRRG GPATCH2L GSE1 HSF2BP KIF3A KLF10 KRTAP10-1 KRTAP10-5 KRTAP10-7 MAGEA6 MAP3K5 MBTD1 MGA MORF4L1 MYBPC2 MYH3 MYH7 MYO18B NCOR1 NFE2L1 NOSTRIN NRIP1 PAF1 PCGF6 PDE4DIP PHAX PSTPIP1 RCOR3 RIOK3 RNF10 ROPN1 RYR1 SLAIN2 SPTB SRP72 TNNT1 TNNT3 WNK1 ZFAT ZNF160 ZNF462 ZNF619 ZNF793 ZNF835 ZSCAN23	6 interacting genes: APC KDM1A MAGEA6 NOS3 PRMT6 TULP3
Entrez ID		7289	115677
HPRD ID		05292	06324
Ensembl ID		ENSG00000078246	ENSG00000163072
Uniprot IDs		B7Z1E7 O75386	Q8IVI9
PDB IDs		8FH3	2YUN
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Actomyosin Structure Organization Cytoskeleton Organization Regulation Of RNA Metabolic Process Myosin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Skeletal Muscle Contraction Actin Filament-based Process H Zone Striated Muscle Contraction Myofibril Actin Cytoskeleton Organization Sarcomere Actin Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Microtubule Plus-end Myosin II Complex Organelle Organization I Band Histone Deacetylase Binding Z Disc Extrinsic Component Of Postsynaptic Density Membrane Striated Muscle Cell Development Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization DNA Binding Transition Between Fast And Slow Fiber Muscle System Process Negative Regulation Of RNA Metabolic Process Troponin Complex Cardiac Muscle Cell Development Muscle Cell Development Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Regulation Of Primary Metabolic Process Cardiac Cell Development Microtubule-based Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Adaptation Myosin Complex Actin Filament Binding	Endocardial Cushion Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Smooth Muscle Hyperplasia Flavin Adenine Dinucleotide Binding Negative Regulation Of Muscle Hyperplasia Bronchus Morphogenesis Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Intraciliary Transport Particle A Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Demethylase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Glycosylceramide Catabolic Process Cadmium Ion Binding MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Localization To Centrosome Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Smooth Muscle Adaptation Regulation Of Systemic Arterial Blood Pressure By Endothelin L-arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Binding Embryonic Neurocranium Morphogenesis Response To Fungicide Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ovulation From Ovarian Follicle Tetrahydrobiopterin Metabolic Process
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