TTF1 and PTRF

Number of citations of the paper that reports this interaction (PMID 9582279)
32

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		TTF1	PTRF
Gene Name		transcription termination factor, RNA polymerase I	polymerase I and transcript release factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	DNA Binding Chromatin Binding	Protein Binding RRNA Primary Transcript Binding Poly(A) RNA Binding
	Biological Process	Chromatin Remodeling DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: BAZ2A KAT2B NFATC3 PTRF SMAD1 SMAD7	3 interactors: NKX2-1 TTF1 ZNF148
Entrez ID		7270	284119
HPRD ID		02866	04433
Ensembl ID		ENSG00000125482	ENSG00000177469
Uniprot IDs		Q15361	Q6NZI2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Histone H3-K9 Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated BMP Signaling Pathway Nitrogen Compound Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterochromatin Assembly Involved In Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Biosynthetic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Morphogenesis Mesonephros Development Regulation Of Transcription From RNA Polymerase II Promoter Tube Development Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development N-terminal Peptidyl-lysine Acetylation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Cardiovascular System Development Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development	Neural Nucleus Development Globus Pallidus Development Type II Pneumocyte Differentiation Clara Cell Differentiation Forebrain Dorsal/ventral Pattern Formation Cerebral Cortex GABAergic Interneuron Differentiation Lung Secretory Cell Differentiation GABAergic Neuron Differentiation Lung Saccule Development Positive Regulation Of Circadian Rhythm Forebrain Neuron Fate Commitment Leydig Cell Differentiation Negative Regulation Of Epithelial To Mesenchymal Transition Forebrain Regionalization Thyroid Gland Development Cerebral Cortex Neuron Differentiation Negative Regulation Of Stem Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Induction Lung Alveolus Development Pituitary Gland Development Regulation Of Epithelial To Mesenchymal Transition Lung Epithelial Cell Differentiation Forebrain Neuron Differentiation Lung Cell Differentiation Lung Morphogenesis Lung Epithelium Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hippocampus Development Oligodendrocyte Differentiation Forebrain Generation Of Neurons Neuron Fate Commitment Brain Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Endoderm Development Head Development Cerebral Cortex Cell Migration Diencephalon Development Regulation Of Circadian Rhythm Transcription From RNA Polymerase II Promoter Limbic System Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Central Nervous System Development Dorsal/ventral Pattern Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		able activate binds cotransfection differentiation essential experiments finding hormone importance main maintenance markers minimal modulation mutated nonthyroid promoter promoters shows step strengthens thyroglobulin thyroid thyroperoxidase trans transcription tsh tshr	aggressiveness angiogenesis angiogenic caveola caveolae caveolin cavin conditioned densities du145 ecs ectopic ex experimentally exploited lncap lymphangiogenesis lymphatic manipulated namely orthotopic pc3 prostate secreted specialized subdomains trafficking transcript vessel
Tagcloud (Difference) ?		able activate binds cotransfection differentiation essential experiments finding hormone importance main maintenance markers minimal modulation mutated nonthyroid promoter promoters shows step strengthens thyroglobulin thyroid thyroperoxidase trans transcription tsh tshr	aggressiveness angiogenesis angiogenic caveola caveolae caveolin cavin conditioned densities du145 ecs ectopic ex experimentally exploited lncap lymphangiogenesis lymphatic manipulated namely orthotopic pc3 prostate secreted specialized subdomains trafficking transcript vessel
Tagcloud (Intersection) ?