TTF1

Gene Name		transcription termination factor, RNA polymerase I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding
	Biological Process	Chromatin Remodeling DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Negative Regulation Of DNA Replication Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: BAZ2A KAT2B NFATC3 PTRF SMAD1 SMAD7
Entrez ID		7270
HPRD ID		02866
Ensembl ID		ENSG00000125482
Uniprot IDs		Q15361
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Histone H3-K9 Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated BMP Signaling Pathway Nitrogen Compound Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterochromatin Assembly Involved In Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Biosynthetic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Morphogenesis Mesonephros Development Regulation Of Transcription From RNA Polymerase II Promoter Tube Development Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development N-terminal Peptidyl-lysine Acetylation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Chromatin Remodeling Cardiovascular System Development Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development
Tagcloud ?		able activate binds cotransfection differentiation essential experiments finding hormone importance main maintenance markers minimal modulation mutated nonthyroid promoter promoters shows step strengthens thyroglobulin thyroid thyroperoxidase trans transcription tsh tshr