JPH3 and CACNA1D

Number of citations of the paper that reports this interaction (PubMedID 31461656)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		JPH3	CACNA1D
Description		junctophilin 3	calcium voltage-gated channel subunit alpha1 D
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Junctional Membrane Complex	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Z Disc T-tubule Monoatomic Ion Channel Complex L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Cytoskeletal Protein Binding High Voltage-gated Calcium Channel Activity Ankyrin Binding Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential
	Biological Process	Learning Memory Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Exploration Behavior Locomotion Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Calcium Ion Transport Into Cytosol	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Cell Communication Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of Metal Ion Transport Signaling Monoatomic Ion Transmembrane Transport Positive Regulation Of Adenylate Cyclase Activity Nervous System Process Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Sensory processing of sound by inner hair cells of the cochlea
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases		Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS); Huntington's disease-like 2 (HDL2); Pantothenate kinase associated neurodegeneration (PKAN)
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Late-onset Alzheimer's disease ( 27770636) Migraine ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Refractive error ( 32231278) Small vessel stroke ( 27997041) Systemic juvenile idiopathic arthritis ( 27927641)	Age at first sexual intercourse ( 34211149 27089180) Appendicular lean mass ( 33097823) Axial length ( 24144296) Body mass index ( 25673413) Body size at age 10 ( 32376654) Diastolic blood pressure ( 25249183 30578418 29403010 30487518) Electrocardiographic traits ( 25055868) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hypertension ( 25249183 30487518) Insomnia ( 29520036) Insulin resistance/response ( 21901158) Mean arterial pressure ( 29403010 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) PR interval ( 32439900) Pulse pressure ( 30487518) Pursuit maintenance gain ( 29064472) Refractive error ( 23396134 32231278) Resting heart rate ( 27798624) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418 30487518 25249183 29403010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920)
Interacting Genes		11 interacting genes: BGN CACNA1D CCR2 KCNN4 KRTAP10-8 PPP1CA RSPH1 RYR2 SMAD3 SMO TSHR	7 interacting genes: CALB1 FGFR2 JPH3 JPH4 KCNN4 RYR2 STX1A
Entrez ID		57338	776
HPRD ID		05589	00247
Ensembl ID		ENSG00000154118	ENSG00000157388
Uniprot IDs		B4DIC1 F8W9A3 Q8WXH2 Q96HD8	A0A1B0GUN6 Q01668 Q59GD8
PDB IDs			3LV3 7UHF 7UHG 8E59 8E5A 8E5B
Enriched GO Terms of Interacting Partners?		Epithelial Tube Morphogenesis Tube Morphogenesis Morphogenesis Of An Epithelium Embryonic Heart Tube Morphogenesis Protein Kinase A Catalytic Subunit Binding Tissue Morphogenesis Blood Vessel Remodeling Cytokine Binding Cell Communication Regulation Of Transport Regulation Of Membrane Potential Regulation Of Biological Quality Regulation Of Calcium Ion Transport Calcium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Signaling Cardiac Muscle Cell Action Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Homeostasis Intermediate Conductance Calcium-activated Potassium Channel Activity Positive Regulation Of Protein Transport Protein Stabilization Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Protein Import Into Nucleus Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Homeostasis Of Number Of Cells Within A Tissue Cellular Response To Thyrotropin-releasing Hormone Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Regulation Of Monoatomic Ion Transmembrane Transport Homeostatic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Heart Looping Regulation Of Potassium Ion Transmembrane Transport Tissue Remodeling Calcium Ion Transmembrane Import Into Cytosol G Protein-coupled Receptor Signaling Pathway Calcium Channel Activity Positive Regulation Of Transport Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Regulation Of Heart Rate Plasma Membrane	Junctional Sarcoplasmic Reticulum Membrane Calcium Ion Transport Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Junctional Membrane Complex Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Metal Ion Transport Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Sequestering Of Calcium Ion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Endoplasmic Reticulum Calcium-mediated Signaling Regulation Of Muscle Contraction Regulation Of System Process Metal Ion Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Heart Contraction Regulation Of Synaptic Plasticity Regulation Of Biological Quality System Process Inorganic Ion Transmembrane Transport Regulation Of Muscle System Process Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Transport Learning Or Memory Ventricular Cardiac Muscle Tissue Morphogenesis Neuromuscular Process Controlling Balance Cognition Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Tissue Morphogenesis Monoatomic Ion Transport Neuron Projection Metanephric Connecting Tubule Development Kidney Epithelium Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Signaling
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