TSN and HOXC4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		TSN	HOXC4
Description		translin	homeobox C4
Image			No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Endoribonuclease Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Metabolic Process SiRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing	Skeletal System Development Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Morphogenesis Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways		Small interfering RNA (siRNA) biogenesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration ( 29346644) Erectile dysfunction and prostate cancer treatment ( 20932654) Food antigen IgG levels ( 24962563) Hepcidin/ferritin ratio ( 27846281) Major depressive disorder x sex interaction ( 34099189) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 34074324)	A body shape index ( 34021172) Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 30578418 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418 27841878 27618447) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		17 interacting genes: CEBPA DVL3 FXR1 GIT2 GORASP2 HOXC4 LNX1 MORF4L2 NTAQ1 PICK1 PPP1R15A SDCBP SIN3A TSNAX UBE2I UBE2K ZBTB18	18 interacting genes: APP CLK3 CSNK2A1 ELMOD2 EXOSC5 HTT NCK2 NSD3 PRKDC PRMT5 PRMT6 RCHY1 RNF32 RPRD1B SOX10 SUV39H1 TSN XRCC6
Entrez ID		7247	3221
HPRD ID		08993	00860
Ensembl ID		ENSG00000211460	ENSG00000198353
Uniprot IDs		B3KRM8 Q15631	P09017 Q86TF7
PDB IDs		1J1J 3PJA 3QB5 4WYV
Enriched GO Terms of Interacting Partners?			Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Nucleic Acid Metabolic Process Nucleoplasm Regulation Of Metabolic Process Histone Arginine N-methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy DNA-dependent Protein Kinase Complex Histone H4R3 Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-dependent Protein Kinase-DNA Ligase 4 Complex Negative Regulation Of Biosynthetic Process Methyltransferase Activity Nonhomologous End Joining Complex Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling RNA Metabolic Process Protein-arginine N-methyltransferase Activity Methylation P53 Binding Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Damage Response Positive Regulation Of Protein Metabolic Process Rhythmic Process Macromolecule Metabolic Process Chromatin Organization DNA Repair Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Transferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Identical Protein Binding Positive Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Post-transcriptional Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process
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