TSN and PPP1R15A

Number of citations of the paper that reports this interaction (PMID 10434033)
3

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		TSN	PPP1R15A
Gene Name		translin	protein phosphatase 1, regulatory subunit 15A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	DNA Binding Single-stranded DNA Binding MRNA Binding Endoribonuclease Activity Protein Binding Protein Complex Binding Sequence-specific DNA Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity
	Biological Process	DNA Recombination Gene Expression RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Regulatory RNA pathways Small interfering RNA (siRNA) biogenesis	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		4 interactors: GIT2 PPP1R15A TSNAX ZBTB18	16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		7247	23645
HPRD ID		08993	06572
Ensembl ID		ENSG00000211460	ENSG00000087074
Uniprot IDs		B3KRM8 Q15631	O75807
PDB IDs		1J1J 3PJA 3QB5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Translation In Response To Stress Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Translational Initiation Regulation Of Translation In Response To Stress	Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		bax bcl cardiomyocyte circumferential commencing cvf d18 diameter distilled eosin gieson hematoxylin hypertensive iia immunohistological lvh lvmi pcva perivascular pvca s18 s8 sacrificed sbp shrs spontaneously tanshinone van ventricular	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Difference) ?		bax bcl cardiomyocyte circumferential commencing cvf d18 diameter distilled eosin gieson hematoxylin hypertensive iia immunohistological lvh lvmi pcva perivascular pvca s18 s8 sacrificed sbp shrs spontaneously tanshinone van ventricular	ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Intersection) ?