PPP1R15A and KIF3A

Number of citations of the paper that reports this interaction (PMID 10631107)
3

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PPP1R15A	KIF3A
Gene Name		protein phosphatase 1, regulatory subunit 15A	kinesin family member 3A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Centrosome Cytosol Spindle Microtubule Microtubule Cytoskeleton Kinesin II Complex Extracellular Vesicular Exosome Primary Cilium Ciliary Tip
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Spectrin Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation	Organelle Organization Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neurogenesis Cilium Assembly Cilium Morphogenesis Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Organelle biogenesis and maintenance Hedgehog 'off' state Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Hedgehog 'on' state MHC class II antigen presentation Signaling by Hedgehog Adaptive Immune System Activation of SMO
Drugs
Diseases
GWAS			Atopic dermatitis ( 23042114 22197932)
Protein-Protein Interactions		16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	13 interactors: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR VHL
Entrez ID		23645	11127
HPRD ID		06572	05250
Ensembl ID		ENSG00000087074	ENSG00000131437
Uniprot IDs		O75807	E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process	Microtubule-based Transport Response To Stress Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Cellular Response To Stress Activation Of JNKK Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Microtubule-based Movement Positive Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Phosphorylation Activation Of MAPK Activity Response To Ionizing Radiation Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Modification Process Response To Radiation Positive Regulation Of Catalytic Activity Cell Death Death Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of MAP Kinase Activity Regulation Of Body Fluid Levels Activation Of JUN Kinase Activity MAPK Cascade Wound Healing Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Axon Cargo Transport Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Organelle Transport Along Microtubule Signal Transduction By Phosphorylation Response To Wounding Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Protein Kinase Activity Developmental Process Activation Of MAPKK Activity Regulation Of Protein Metabolic Process
Tagcloud ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic	aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt
Tagcloud (Difference) ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic	aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt
Tagcloud (Intersection) ?