PPP1R15A and HABP4

Number of citations of the paper that reports this interaction (PMID 16455055)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPP1R15A	HABP4
Gene Name		protein phosphatase 1, regulatory subunit 15A	hyaluronan binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Sarcomere
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity	Protein Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation	Platelet Degranulation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Platelet Activation Negative Regulation Of DNA Binding Cellular Response To Mechanical Stimulus
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	24 interactors: C1QBP CHD3 DAXX ENO2 FRA10AC1 GNB2L1 HMGXB4 KAT5 PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1
Entrez ID		23645	22927
HPRD ID		06572	13628
Ensembl ID		ENSG00000087074	ENSG00000130956
Uniprot IDs		O75807	Q5JVS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Blood Coagulation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Hemostasis Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Platelet Activation Viral Process Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process Response To Wounding Chromatin Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Phospholipase Activity Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Phospholipase Activity Histone H3-T6 Phosphorylation Positive Regulation Of Lipase Activity Chromatin Modification Enzyme Linked Receptor Protein Signaling Pathway Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Death Protein Sumoylation
Tagcloud ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic	9q altered cgi contexts experimentally explain familiar functionally give haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt serbp1 shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Difference) ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic	9q altered cgi contexts experimentally explain familiar functionally give haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt serbp1 shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Intersection) ?