PPP1R15A and POU3F3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PPP1R15A	POU3F3
Description		protein phosphatase 1 regulatory subunit 15A	POU class 3 homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Eukaryotic Initiation Factor EIF2 Binding Protein Phosphatase Activator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Regulation Of Translation Regulation Of Translational Initiation Apoptotic Process DNA Damage Response Positive Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of PERK-mediated Unfolded Protein Response	Kidney Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Chemical Homeostasis Urea Transmembrane Transport Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation
Pathways		Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency	Nephron development
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Adult body size ( 32376654) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Response to taxane treatment (docetaxel) ( 23006423) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	5 interacting genes: POU3F4 PPP1R15A SOX10 SOX11 SOX8
Entrez ID		23645	5455
HPRD ID		06572	03922
Ensembl ID		ENSG00000087074	ENSG00000198914
Uniprot IDs		O75807	P20264
PDB IDs		4XPN 7NXV 7NZM 8QZZ
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Translational Initiation In Response To Stress Cellular Response To Heat Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Heat Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translational Initiation Viral Genome Replication Regulation Of Translation In Response To Stress Protein-containing Complex Binding Response To Temperature Stimulus Nucleus Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Translation Initiation Ternary Complex Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Metanephric DCT Cell Differentiation Cell Division Metanephric Macula Densa Development Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Glycogen Metabolic Process Positive Regulation Of Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Protein Metabolic Process Denatured Protein Binding Positive Regulation Of Oligodendrocyte Progenitor Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Metanephric Thick Ascending Limb Development	Regulation Of Gliogenesis Sequence-specific Double-stranded DNA Binding Enteric Nervous System Development DNA-binding Transcription Factor Activity Negative Regulation Of Glial Cell Proliferation Oligodendrocyte Development Positive Regulation Of Neurogenesis Peripheral Nervous System Development Positive Regulation Of Nervous System Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Oligodendrocyte Differentiation Morphogenesis Of An Epithelium Regulation Of Neurogenesis Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Gliogenesis Positive Regulation Of Gene Expression Glial Cell Development Tissue Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Cell Development Regulation Of Nervous System Development Animal Organ Development Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Positive Regulation Of Lens Epithelial Cell Proliferation Glial Cell Differentiation Ameboidal-type Cell Migration Negative Regulation Of Cell Differentiation Closure Of Optic Fissure Negative Regulation Of Neurogenesis Negative Regulation Of Nervous System Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Cell Maturation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Translational Initiation In Response To Stress Eukaryotic Initiation Factor EIF2 Binding Renal Vesicle Induction DNA Binding Negative Regulation Of Apoptotic Process Regulation Of Cell Development Cell Development DNA-binding Transcription Factor Binding Positive Regulation Of Cell Differentiation Cellular Response To Progesterone Stimulus
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