PPP1R15A and PPP1R1A

Number of citations of the paper that reports this interaction (PMID 11564868)
58

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PPP1R15A	PPP1R1A
Gene Name		protein phosphatase 1, regulatory subunit 15A	protein phosphatase 1, regulatory (inhibitor) subunit 1A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Regulator Activity Protein Kinase Binding Protein Phosphatase Type 1 Activator Activity	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation	Glycogen Metabolic Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	1 interactors: PPP1R15A
Entrez ID		23645	5502
HPRD ID		06572	17893
Ensembl ID		ENSG00000087074	ENSG00000135447
Uniprot IDs		O75807	Q13522 R4GMQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Protein Refolding Gene Expression Viral Genome Replication Blood Coagulation Cell Division Hemostasis Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Viral Life Cycle Regulation Of Cellular Process Platelet Activation Cellular Metabolic Process B Cell Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Body Fluid Levels Wound Healing Cellular Response To Stimulus Positive Regulation Of Oligodendrocyte Progenitor Proliferation Metanephric Macula Densa Development Metanephric DCT Cell Differentiation Positive Regulation Of Cellular Response To Drug Negative Regulation Of Mast Cell Proliferation Glycogen Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Response To Wounding Platelet Degranulation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Heat Acclimation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Polysaccharide Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Translation In Response To Stress Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Protein Dephosphorylation Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Translational Initiation Regulation Of Translation In Response To Stress Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Protein Dephosphorylation Positive Regulation Of Phosphatase Activity Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Dephosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Translation Positive Regulation Of Peptidyl-serine Phosphorylation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Regulation Of Phosphatase Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation ER-nucleus Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Topologically Incorrect Protein Protein Localization To Endoplasmic Reticulum Regulation Of Dephosphorylation Response To Unfolded Protein Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Translation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Difference) ?		ablation antihypertensive approved arm attenuation chop dephosphorylates effector eif2alpha ersr fda gadd34 guanabenz hallmark hindlimb improvements injuries locomotion locomotor misfolded oligodendrocyte opcs perk protected protects rescue restoration sci traumatic
Tagcloud (Intersection) ?