PPP1R15A and PPP1R1A

Number of citations: 68 (PubMedID 11564868)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		PPP1R15A	PPP1R1A
Name		protein phosphatase 1 regulatory subunit 15A	protein phosphatase 1 regulatory inhibitor subunit 1A
Structure			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Eukaryotic Initiation Factor EIF2 Binding Protein Phosphatase Activator Activity	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Translation Regulation Of Translational Initiation Apoptotic Process DNA Damage Response Positive Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of PERK-mediated Unfolded Protein Response	Glycogen Metabolic Process Signal Transduction Intracellular Signal Transduction
Pathways		Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency	None
GWAS		High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Body fat mass ( 28552196 ) Hip circumference ( 28552196 ) Waist circumference ( 28552196 )
Novel Interactors		None recorded	1 novel interactors: RNF41
Interacting Genes		16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	1 interacting genes: PPP1R15A
Entrez ID		23645	5502
HPRD ID		06572	17893
Ensembl ID		ENSG00000087074	ENSG00000135447
Uniprot IDs		O75807	Q13522
PDB IDs		4XPN 7NXV 7NZM 8QZZ	Not available
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Translational Initiation In Response To Stress Cellular Response To Heat Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Heat Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translational Initiation Viral Genome Replication Regulation Of Translation In Response To Stress Protein-containing Complex Binding Response To Temperature Stimulus Nucleus Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Translation Initiation Ternary Complex Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Metanephric DCT Cell Differentiation Cell Division Metanephric Macula Densa Development Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Glycogen Metabolic Process Positive Regulation Of Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Protein Metabolic Process Denatured Protein Binding Positive Regulation Of Oligodendrocyte Progenitor Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Metanephric Thick Ascending Limb Development	Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Apoptotic Signaling Pathway Positive Regulation Of Translational Initiation In Response To Stress Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Negative Regulation Of Mitophagy Endoplasmic Reticulum Tubular Network Programmed Cell Death Protein Phosphatase 1 Binding Protein Phosphatase Activator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macroautophagy Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Phosphatase Regulator Activity Regulation Of Mitophagy Positive Regulation Of Translational Initiation Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagy Of Mitochondrion Receptor Tyrosine Kinase Binding Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination