TRH and CD80

Data Source: HiPPIP (Novel)

		TRH	CD80
Name		thyrotropin releasing hormone	CD80 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Hormone Activity Protein Binding Thyrotropin-releasing Hormone Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Receptor Ligand Activity
	Biological Process	Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior	Immune System Process Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		None	Abatacept Galiximab Belatacept
GWAS		Alzheimer's disease ( 30636644 ) Hip index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Asthma ( 32296059 ) Autoimmune thyroid disease ( 32581359 ) Carotid plaque burden ( 28282560 ) Celiac disease ( 20190752 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446 ) Primary biliary cholangitis ( 21399635 28425483 28062665 26394269 23000144 ) Primary biliary cirrhosis ( 22961000 ) Systemic lupus erythematosus ( 25862617 23273568 ) Systemic sclerosis ( 31672989 ) Vitiligo ( 27723757 22561518 )
Novel Interactors		3 novel interactors: CD80 CD86 IQCB1	4 novel interactors: IQCB1 MRPL3 TRH UPK1B
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		7200	941
HPRD ID		08944	00202
Ensembl ID		ENSG00000170893	ENSG00000121594
Uniprot IDs		P20396	A0N0P2 P33681
PDB IDs		Not available	1DR9 1I8L 7TPS 8FXW 8FXZ 8HXA
GO Terms Enriched among Interactors		Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of T-helper Cell Differentiation Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Hippocampal Neuron Apoptotic Process Thyrotropin-releasing Hormone Receptor Activity Angiotensin Receptor Binding Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Virus Receptor Activity Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity BBSome Binding Cellular Response To Lipid Positive Regulation Of T Cell Proliferation Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Gene Expression Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Symbiont Entry Into Host Cell Positive Regulation Of Lymphotoxin A Production Protein Localization To Secretory Granule Siderophore Transport Negative Regulation Of Immune System Process Receptor Ligand Activity Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Maintenance Of Animal Organ Identity Positive Regulation Of Developmental Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway	T Cell Costimulation Regulation Of T Cell Proliferation Protein Complex Involved In Cell Adhesion Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation External Side Of Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-4 Production Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Regulation Of Interleukin-4 Production Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cell Activation Positive Regulation Of Interleukin-10 Production Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Immunoglobulin Production Adaptive Immune Response Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Interleukin-2 Production Regulation Of Interleukin-10 Production Thyrotropin-releasing Hormone Activity Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process