TRH and TRHR

Number of citations: 0 (PubMedID 9794253)
Data Source: HPRD (in vitro, in vivo)

		TRH	TRHR
Name		thyrotropin releasing hormone	thyrotropin releasing hormone receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Protein Binding Thyrotropin-releasing Hormone Activity	G Protein-coupled Receptor Activity Thyrotropin-releasing Hormone Receptor Activity Protein Binding
	Biological Process	Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		None	Protirelin
GWAS		Alzheimer's disease ( 30636644 ) Hip index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Body mass (lean) ( 19268274 ) Daytime sleep phenotypes ( 27126917 ) LDL cholesterol levels ( 32203549 ) Night sleep phenotypes ( 27126917 ) Pulse pressure ( 30224653 ) Type 2 diabetes ( 30297969 )
Novel Interactors		3 novel interactors: CD80 CD86 IQCB1	None recorded
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR	19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6
Entrez ID		7200	7201
HPRD ID		08944	11767
Ensembl ID		ENSG00000170893	ENSG00000174417
Uniprot IDs		P20396	P34981
PDB IDs		Not available	7WKD 7X1T 7X1U 7XW9
GO Terms Enriched among Interactors		Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of T-helper Cell Differentiation Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Hippocampal Neuron Apoptotic Process Thyrotropin-releasing Hormone Receptor Activity Angiotensin Receptor Binding Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Virus Receptor Activity Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity BBSome Binding Cellular Response To Lipid Positive Regulation Of T Cell Proliferation Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Gene Expression Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Symbiont Entry Into Host Cell Positive Regulation Of Lymphotoxin A Production Protein Localization To Secretory Granule Siderophore Transport Negative Regulation Of Immune System Process Receptor Ligand Activity Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Maintenance Of Animal Organ Identity Positive Regulation Of Developmental Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway	Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport