TRH and TRHR

Number of citations of the paper that reports this interaction (PMID 15117874)
3

Data Source:
HPRD (in vivo, in vitro)

		TRH	TRHR
Gene Name		thyrotropin-releasing hormone	thyrotropin-releasing hormone receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Neuropeptide Hormone Activity Thyrotropin-releasing Hormone Activity	Thyrotropin-releasing Hormone Receptor Activity
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior	G-protein Coupled Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Body mass (lean) ( 19268274)
Protein-Protein Interactions		3 interactors: ARRB2 CPE TRHR	2 interactors: ARRB1 TRH
Entrez ID		7200	7201
HPRD ID		08944	11767
Ensembl ID		ENSG00000170893	ENSG00000174417
Uniprot IDs		P20396	P34981
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Synaptic Transmission, Dopaminergic Insulin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of DNA Biosynthetic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-12 Production Regulation Of Androgen Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Toll-like Receptor Signaling Pathway Detection Of Temperature Stimulus Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Negative Regulation Of Mitochondrion Organization Negative Regulation Of GTPase Activity Peptide Hormone Processing Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Receptor Internalization Regulation Of DNA Biosynthetic Process Adult Walking Behavior Regulation Of Interleukin-1 Beta Production Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Interleukin-12 Production Negative Regulation Of NF-kappaB Transcription Factor Activity Ovarian Follicle Development Cardiac Ventricle Morphogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling	Positive Regulation Of Insulin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Protein Secretion Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Positive Regulation Of Secretion Positive Regulation Of Protein Transport Histamine Metabolic Process Regulation Of Protein Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Histone H4 Acetylation Regulation Of Protein Transport Regulation Of Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Amino Acid Transport Positive Regulation Of Transport Regulation Of Glutamate Secretion G-protein Coupled Receptor Internalization Regulation Of Protein Localization Regulation Of Feeding Behavior Negative Regulation Of Interleukin-8 Production Stress Fiber Assembly Regulation Of Histone H4 Acetylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of Histone Acetylation Regulation Of Cellular Localization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Response To Abiotic Stimulus Eating Behavior Regulation Of Receptor Internalization Response To Corticosterone Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Response To Mineralocorticoid Receptor Internalization Regulation Of Histone Acetylation Adult Walking Behavior Positive Regulation Of Ras Protein Signal Transduction Response To Cold Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Tagcloud ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon
Tagcloud (Difference) ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon
Tagcloud (Intersection) ?