TRH

Description		thyrotropin releasing hormone
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule
	Molecular Function	Hormone Activity Protein Binding Thyrotropin-releasing Hormone Activity
	Biological Process	Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) Hip index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		3 novel interacting genes: CD80 CD86 IQCB1
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR
Entrez ID		7200
HPRD ID		08944
Ensembl ID		ENSG00000170893
Uniprot IDs		P20396
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of T-helper Cell Differentiation Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Hippocampal Neuron Apoptotic Process Thyrotropin-releasing Hormone Receptor Activity Angiotensin Receptor Binding Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Virus Receptor Activity Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity BBSome Binding Cellular Response To Lipid Positive Regulation Of T Cell Proliferation Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Gene Expression Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Symbiont Entry Into Host Cell Positive Regulation Of Lymphotoxin A Production Protein Localization To Secretory Granule Siderophore Transport Negative Regulation Of Immune System Process Receptor Ligand Activity Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Maintenance Of Animal Organ Identity Positive Regulation Of Developmental Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
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