TRH and CPE

Number of citations of the paper that reports this interaction (PubMedID 12270926)
0

Data Source:
HPRD (in vivo)

		TRH	CPE
Description		thyrotropin releasing hormone	carboxypeptidase E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Endomembrane System Membrane Transport Vesicle Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Thyrotropin-releasing Hormone Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Neurexin Family Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior	Cardiac Left Ventricle Morphogenesis Proteolysis Peptide Metabolic Process Cell Communication Neuropeptide Signaling Pathway Intracellular Protein Localization Wnt Signaling Pathway Protein Processing Signaling Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Modification Process Protein Localization To Membrane
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Insulin processing
Drugs			Insulin human
Diseases
GWAS		Alzheimer's disease ( 30636644) Hip index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR	18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		7200	1363
HPRD ID		08944	00272
Ensembl ID		ENSG00000170893	ENSG00000109472
Uniprot IDs		P20396	A0A384N679 P16870
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of T-helper Cell Differentiation Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Hippocampal Neuron Apoptotic Process Thyrotropin-releasing Hormone Receptor Activity Angiotensin Receptor Binding Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Virus Receptor Activity Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity BBSome Binding Cellular Response To Lipid Positive Regulation Of T Cell Proliferation Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Gene Expression Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Symbiont Entry Into Host Cell Positive Regulation Of Lymphotoxin A Production Protein Localization To Secretory Granule Siderophore Transport Negative Regulation Of Immune System Process Receptor Ligand Activity Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Maintenance Of Animal Organ Identity Positive Regulation Of Developmental Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway	Hormone Activity Feeding Behavior Receptor Ligand Activity Axolemma G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cell Junction Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Hormone Activity Eating Behavior Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Extracellular Region Positive Regulation Of Glucose Metabolic Process Regulation Of Peptide Hormone Secretion Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Neuron Recognition Thyrotropin-releasing Hormone Activity
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