TRHR and NIPAL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRHR	NIPAL4
Description		thyrotropin releasing hormone receptor	NIPA like domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thyrotropin-releasing Hormone Receptor Activity Protein Binding	Protein Binding Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Monoatomic Ion Transport Magnesium Ion Transport Magnesium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Miscellaneous transport and binding events
Drugs		Protirelin
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)	Asthma ( 31959851)
Interacting Genes		19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6	15 interacting genes: ACKR2 CLDN7 CMTM2 COMT FFAR2 GJB1 GPR152 HHLA2 IL10RA LHFPL5 RNF185 RNF19B SSMEM1 TM4SF18 TRHR
Entrez ID		7201	348938
HPRD ID		11767	19424
Ensembl ID		ENSG00000174417	ENSG00000172548
Uniprot IDs		P34981	Q0D2K0
PDB IDs		7WKD 7X1T 7X1U 7XW9
Enriched GO Terms of Interacting Partners?		Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport	Membrane
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