TRHR and TMEFF2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TRHR	TMEFF2
Name		thyrotropin releasing hormone receptor	transmembrane protein with EGF like and two follistatin like domains 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thyrotropin-releasing Hormone Receptor Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Response To Stress Cell Differentiation Negative Regulation Of Cell Migration Wound Healing, Spreading Of Cells Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Stress Fiber Assembly
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	None
Drugs		Protirelin	None
GWAS		Body mass (lean) ( 19268274 ) Daytime sleep phenotypes ( 27126917 ) LDL cholesterol levels ( 32203549 ) Night sleep phenotypes ( 27126917 ) Pulse pressure ( 30224653 ) Type 2 diabetes ( 30297969 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Adverse response to drug ( 30420678 ) CSF tryptophan concentration in tuberculous meningitis ( 29395996 ) Diabetes (incident) ( 17903298 ) Schizophrenia ( 33169155 ) Sudden cardiac arrest ( 21658281 )
Novel Interactors		None recorded	2 novel interactors: DNAH7 STAT4
Interacting Genes		19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6	10 interacting genes: DRD2 HSF2BP HTR4 NBPF19 NOTCH2NLA RIC3 TMEM237 TRHR UBIAD1 ZDHHC15
Entrez ID		7201	23671
HPRD ID		11767	05760
Ensembl ID		ENSG00000174417	ENSG00000144339
Uniprot IDs		P34981	Q9UIK5
PDB IDs		7WKD 7X1T 7X1U 7XW9	Not available
GO Terms Enriched among Interactors		Magnesium Ion Transport Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport	None