EBF2

Name	EBF transcription factor 2
Structure	No pdb structure
Interactors	3 interactors: EBF3 TRAF1 TRAF2
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Fate Determination Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Adipose Tissue Development Positive Regulation Of Cold-induced Thermogenesis
Pathways	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
GWAS	Body size at age 10 ( 32376654 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Dupuytren's disease ( 28886342 ) Hip index ( 34021172 ) Inguinal hernia ( 26686553 ) Major depressive disorder ( 27479909 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Multiple system atrophy ( 27629089 ) Prostate cancer ( 23535732 ) Systolic blood pressure ( 27841878 28739976 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	64641
HPRD ID	16848
Ensembl ID	ENSG00000221818
Uniprot IDs	B2RNT0 B7Z934 Q9HAK2
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Ubiquitin Protein Ligase Binding CD27 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Zinc Ion Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Programmed Necrotic Cell Death Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of MAP Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-2 Production Vesicle Membrane Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Regulation Of RNA Metabolic Process Apoptotic Process Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process