Wiki-Pi
About
Search
People
Updates
Search
C3 and HMGB1
Number of citations of the paper that reports this interaction (PubMedID
29721183
)
101
Data Source:
BioGRID
(two hybrid)
C3
HMGB1
Description
complement C3
high mobility group box 1
Image
GO Annotations
Cellular Component
Extracellular Region
Classical-complement-pathway C3/C5 Convertase Complex
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Cell Surface
Protein-containing Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Extracellular Exosome
Blood Microparticle
Symbiont Cell Surface
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Cell Surface
Membrane
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Molecular Function
Antigen Binding
Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Chemokine Activity
C5L2 Anaphylatoxin Chemotactic Receptor Binding
Receptor Ligand Activity
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Cis-regulatory Region Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Lipid Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
Receptor Ligand Activity
RAGE Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Polymerase Binding
Supercoiled DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Positive Regulation Of Type IIa Hypersensitivity
Complement Activation, Lectin Pathway
Activation Of Membrane Attack Complex
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Activation Of Membrane Attack Complex
Immune System Process
Complement Receptor Mediated Signaling Pathway
Lipid Metabolic Process
Fatty Acid Metabolic Process
Inflammatory Response
Immune Response
Complement Activation
Complement Activation, Alternative Pathway
Complement Activation, Classical Pathway
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Opsonization
Response To Bacterium
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of D-glucose Transmembrane Transport
Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Lipid Storage
Neuron Remodeling
Leukocyte Chemotaxis
Killing Of Cells Of Another Organism
Oviduct Epithelium Development
B Cell Activation
Innate Immune Response
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Phagocytosis
Protein Maturation
Positive Regulation Of Phagocytosis, Engulfment
Amyloid-beta Clearance
Complement-dependent Cytotoxicity
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Complement Activation, GZMK Pathway
Positive Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Activation Of Innate Immune Response
Adaptive Immune Response
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Myeloid Progenitor Cell Differentiation
Immune System Process
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glycogen Catabolic Process
DNA Metabolic Process
DNA Topological Change
DNA Repair
Base-excision Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Autophagy
Chemotaxis
Inflammatory Response
Immune Response
DNA Damage Response
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Myeloid Cell Differentiation
Lung Development
Neuron Projection Development
Heterochromatin Formation
Regulation Of Restriction Endodeoxyribonuclease Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Negative Regulation Of Type II Interferon Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Viral Entry Into Host Cell
Cell Development
Regulation Of Viral Process
Positive Chemotaxis
Regulation Of DNA Metabolic Process
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Sprouting Angiogenesis
Regulation Of Hemopoiesis
Positive Regulation Of Myeloid Progenitor Cell Differentiation
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Pathways
Alternative complement activation
Activation of C3 and C5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Neutrophil degranulation
Post-translational protein phosphorylation
Purinergic signaling in leishmaniasis infection
Regulation of Complement cascade
ER-Phagosome pathway
Apoptosis induced DNA fragmentation
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
TAK1-dependent IKK and NF-kappa-B activation
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Pyroptosis
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Human immunoglobulin G
Zinc
S-Hydroxycysteine
Mirococept
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Pegcetacoplan
Chloroquine
Ethyl pyruvate
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385826
20861866
21665990
23455636
20385819
)
Age-related macular degeneration (choroidal neovascularisation) (
22705344
)
Age-related macular degeneration (geographic atrophy) (
22705344
)
Blood protein levels (
30072576
)
Complement C3 and C4 levels (
23028341
)
Complement C3 levels (
33941608
)
Disease progression in age-related macular degeneration (
29346644
)
Early age-related macular degeneration (
32843070
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
)
Triglycerides (
24097068
)
White blood cell count (
32888494
)
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Rapid response to perioperative phenylephrine (change in mean arterial pressure) (
33168928
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
37 interacting genes:
ABL1
AGR2
ATG16L1
C2
C3AR1
C5
C5AR2
CD46
CFB
CFH
CFHR3
CFHR4
CFHR5
CFI
CFP
CPN1
CR1
CR2
CTSG
EFEMP2
GC
GOLGA6L9
HMGB1
HSP90AA1
ITGAM
ITGAX
ITGB2
KRT31
KRTAP10-8
LAMA1
LRP1
MASP1
OLFM4
PAPPA
PLEKHF2
TGM2
VSIG4
132 interacting genes:
ACBD3
AGER
AGTRAP
AKIP1
AR
ATF7IP
ATOH1
C1QA
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPA
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DAG1
DLAT
DNAAF2
DNM2
DNMT1
DUX4
DYNC2I1
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOS
FOXA3
FOXC1
GOLM1
GTF2A1
HDAC1
HDLBP
HES1
HMGA1
HNRNPK
HNRNPU
HOXA10
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MALAT1
MAP1B
MAPKAPK5
MECP2
MIEN1
MNAT1
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PSMA7
PTPN2
PTPRZ1
RAD23B
RAG1
RASAL2
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
RSF1
SIX5
SOX18
SPIN1
SPINT1
SRSF3
STUB1
TAF1
TAF3
TBP
TERF2
TERF2IP
TFE3
TGIF1
TGM2
TGM3
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBC
UBE2E3
UBE2I
UBXN1
UHRF2
UNC119
USP12
WNK4
YY1
ZFP36
ZNF24
ZNF428
Entrez ID
718
3146
HPRD ID
00400
01228
Ensembl ID
ENSG00000125730
ENSG00000189403
Uniprot IDs
B4DR57
P01024
V9HWA9
B7Z965
P09429
Q5T7C4
PDB IDs
1C3D
1GHQ
1W2S
2A73
2A74
2GOX
2I07
2ICE
2ICF
2NOJ
2QKI
2WII
2WIN
2WY7
2WY8
2XQW
2XWB
2XWJ
3D5R
3D5S
3G6J
3L3O
3L5N
3NMS
3OED
3OHX
3OXU
3RJ3
3T4A
4HW5
4HWJ
4I6O
4M76
4ONT
4ZH1
5FO7
5FO8
5FO9
5FOA
5FOB
5NBQ
5O32
5O35
6EHG
6RMT
6RMU
6RUR
6RUV
6S0B
6YO6
7AKK
7BAG
7NOZ
7PI6
7QIV
7TV9
7UE9
7ZGK
8ENU
8EOK
8HK2
8I9L
8OQ3
8OVB
8UH2
8UIN
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
8I9M
Enriched GO Terms of Interacting Partners
?
Complement Activation
Activation Of Immune Response
Positive Regulation Of Immune Response
Complement Activation, Alternative Pathway
Immune Effector Process
Complement Component C3b Binding
Regulation Of Immune Response
Humoral Immune Response
Positive Regulation Of Immune System Process
Extracellular Space
Regulation Of Immune System Process
Immune System Process
Regulation Of Complement Activation
Defense Response
Response To Other Organism
Response To External Biotic Stimulus
Regulation Of Humoral Immune Response
Immune Response
Defense Response To Symbiont
Defense Response To Other Organism
Innate Immune Response
Complement Receptor Mediated Signaling Pathway
Negative Regulation Of Complement Activation
Regulation Of Complement Activation, Alternative Pathway
Complement Activation, Classical Pathway
Extracellular Region
Complement Receptor Activity
Positive Regulation Of Cell Adhesion
Response To Stress
Extracellular Exosome
Phagocytosis
Symbiont Cell Surface
Regulation Of Cell Adhesion
Negative Regulation Of Immune System Process
Killing Of Cells Of Another Organism
Complement Binding
Negative Regulation Of Complement Activation, Classical Pathway
Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Activation Of Membrane Attack Complex
Complement Activation, Lectin Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Vasculature Development
Cell Killing
Integrin AlphaM-beta2 Complex
Integrin AlphaX-beta2 Complex
Peptidase Activity
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Immune Response
Serine-type Peptidase Activity
Chromatin
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Transcription Regulator Complex
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific DNA Binding
Regionalization
Anterior/posterior Pattern Specification
Transcription Cis-regulatory Region Binding
Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Pattern Specification Process
Positive Regulation Of Developmental Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Macromolecule Biosynthetic Process
Anatomical Structure Morphogenesis
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?