C3 and CFI

Number of citations of the paper that reports this interaction (PubMedID 9291131)
41

Data Source:
HPRD (in vitro)

		C3	CFI
Description		complement C3	complement factor I
Image
GO Annotations	Cellular Component	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle Symbiont Cell Surface	Extracellular Region Extracellular Space Membrane Extracellular Exosome
	Molecular Function	Antigen Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Receptor Ligand Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Opsonization Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Neuron Remodeling Leukocyte Chemotaxis Killing Of Cells Of Another Organism Oviduct Epithelium Development B Cell Activation Innate Immune Response Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phagocytosis Protein Maturation Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance	Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form Pegcetacoplan	Zinc Copper Zinc acetate
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 20861866 21665990 23455636 20385819) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		37 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 HSP90AA1 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4	3 interacting genes: C3 CFH GLP1R
Entrez ID		718	3426
HPRD ID		00400	01955
Ensembl ID		ENSG00000125730	ENSG00000205403
Uniprot IDs		B4DR57 P01024 V9HWA9	A8K3L0 B4DRF2 E7ETH0 G3XAM2 P05156 Q8WW88
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RMT 6RMU 6RUR 6RUV 6S0B 6YO6 7AKK 7BAG 7NOZ 7PI6 7QIV 7TV9 7UE9 7ZGK 8ENU 8EOK 8HK2 8I9L 8OQ3 8OVB 8UH2 8UIN	2XRC 5O32
Enriched GO Terms of Interacting Partners?		Complement Activation Activation Of Immune Response Positive Regulation Of Immune Response Complement Activation, Alternative Pathway Immune Effector Process Complement Component C3b Binding Regulation Of Immune Response Humoral Immune Response Positive Regulation Of Immune System Process Extracellular Space Regulation Of Immune System Process Immune System Process Regulation Of Complement Activation Defense Response Response To Other Organism Response To External Biotic Stimulus Regulation Of Humoral Immune Response Immune Response Defense Response To Symbiont Defense Response To Other Organism Innate Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Extracellular Region Complement Receptor Activity Positive Regulation Of Cell Adhesion Response To Stress Extracellular Exosome Phagocytosis Symbiont Cell Surface Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Killing Of Cells Of Another Organism Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Activation Of Membrane Attack Complex Complement Activation, Lectin Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Cell Killing Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Peptidase Activity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Immune Response Serine-type Peptidase Activity	Complement Activation, Alternative Pathway Regulation Of Complement Activation Symbiont Cell Surface Regulation Of Humoral Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Glucagon Receptor Activity Response To Psychosocial Stress Regulation Of Complement Activation, Alternative Pathway Positive Regulation Of Complement Activation Complement Activation, Lectin Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Immune Effector Process Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Synapse Pruning Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Serine-type Endopeptidase Complex Regulation Of Complement-dependent Cytotoxicity Complement Component C3b Binding Regulation Of Acute Inflammatory Response To Antigenic Stimulus Opsonization Positive Regulation Of Adenylate Cyclase Activity Heparan Sulfate Proteoglycan Binding Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Humoral Immune Response Positive Regulation Of Lipid Storage Positive Regulation Of Cyclase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?