NACAD and MAP4K2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NACAD	MAP4K2
Gene Name		NAC alpha domain containing	mitogen-activated protein kinase kinase kinase kinase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Cytoplasm Basolateral Plasma Membrane
	Molecular Function		Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Protein Transport	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS			Urate levels ( 21768215)
Protein-Protein Interactions		8 interactors: CBLC HDAC6 MAP4K2 NR4A1 PTK2 RPS27 TNNT1 YAE1D1	13 interactors: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6
Entrez ID		23148	5871
HPRD ID			04408
Ensembl ID		ENSG00000136274	ENSG00000168067
Uniprot IDs		O15069	Q12851 Q86VU3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Organelle Localization Endothelial Cell Migration Regulation Of Catalytic Activity Epithelial Cell Migration Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Epithelium Migration Regulation Of Receptor Activity Response To Growth Factor Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteolysis Regulation Of Epithelial Cell Migration Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ameboidal-type Cell Migration Netrin-activated Signaling Pathway Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Cellular Macromolecule Catabolic Process Protein Complex Disassembly Negative Regulation Of Protein Metabolic Process Negative Regulation Of Synapse Assembly Slow-twitch Skeletal Muscle Fiber Contraction Aggresome Assembly Tubulin Deacetylation Positive Regulation Of Oxidative Stress-induced Cell Death Peptidyl-lysine Deacetylation Signal Complex Assembly Fc Receptor Signaling Pathway Cellular Response To Misfolded Protein Regulation Of Protein Phosphorylation Cellular Localization Positive Regulation Of Receptor Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of MAP Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Misfolded Protein Establishment Of Organelle Localization Positive Regulation Of Cellular Metabolic Process Angiogenesis Positive Regulation Of Cell Migration	Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Activation Of JUN Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of DNA Strand Elongation Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Neuron Death DNA Duplex Unwinding DNA Geometric Change Toll-like Receptor 4 Signaling Pathway JNK Cascade Positive Regulation Of MAPK Cascade Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Hyperosmotic Salinity Response Regulation Of Male Germ Cell Proliferation Golgi Vesicle Fusion To Target Membrane Telomere Formation Via Telomerase Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Regulation Of DNA Replication Cellular Response To Sorbitol Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To X-ray
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