TCP10L and PRPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCP10L	PRPH
Description		t-complex 10 like	peripherin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Intermediate Filament Organization
Pathways
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		33 interacting genes: APP CATSPERT CCDC102B CCDC57 CCDC70 CDR2L CIAO1 DAPK3 FBXO25 FHL2 FRS3 IKBKG LMO1 LMO2 LMO3 LRRK2 MAPK9 MFAP1 MXD4 NCK2 NTAQ1 NXF1 PMF1 PRPH RALBP1 SAAL1 SMARCD1 TCEANC TNNC1 TNS2 TRIM55 TRIM63 TSSK3	34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		140290	5630
HPRD ID		10518	01365
Ensembl ID		ENSG00000242220	ENSG00000135406
Uniprot IDs		Q8TDR4	B3KWQ6 P41219
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Manganese Ion Negative Regulation Of Response To Endoplasmic Reticulum Stress	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization
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