RAD23A and MKRN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAD23A	MKRN1
Description		RAD23 nucleotide excision repair protein A	makorin ring finger protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex	Cytosol
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding Ubiquitin-specific Protease Binding	RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Protein Destabilization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Cell Cycle	Protein Polyubiquitination Protein Ubiquitination
Pathways		Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Immature fraction of reticulocytes ( 32888494) Number of sexual partners ( 30643258)
Interacting Genes		79 interacting genes: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CDC37 CEBPA CHEK1 CNTROB CREBBP DAZAP2 DBI ECSIT EP300 EWSR1 FILIP1 GTF2H1 H4C1 HSPB1 IFIT3 IFIT5 KRTAP12-2 LOXL4 MAP3K1 MAST1 MDM2 MINDY3 MKRN1 MPG NEDD8 NGLY1 NUTM2F OGT PDE6D PHAX PI4K2A PRKN PSEN1 PSMC5 PSMD4 RABGEF1 REL RNF115 RNF32 RNF41 RPN1 RPS27A SH3RF1 SMURF1 SQSTM1 TNFAIP3 TRAF2 TRAF3 TRAF5 TRAF6 TRIM39 TRIM50 TRIM54 TRIM55 TRIM8 TRIP6 UBA52 UBB UBC UBE3A UBE4B UBL7 UBQLN4 UBXN1 UIMC1 USP25 VAV2 WWP2 XPC ZBTB26 ZBTB44 ZBTB8A ZFAND6	28 interacting genes: APC ASH2L BYSL CDKN2A CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A KCNH1 MAP1LC3B MTURN NAA10 OTUB2 PABPC1 RAD23A RAD23B RPS10 SDCBP SLC13A1 TSC2 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1
Entrez ID		5886	23608
HPRD ID		07191	09673
Ensembl ID		ENSG00000179262	ENSG00000133606
Uniprot IDs		A8K1J3 P54725	Q9UHC7
PDB IDs		1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 2WYQ 5XBO 6W2G 6W2H 6W2I 6XQI 6XQJ 7TGP 8Q06
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Protein Polyubiquitination Protein Autoubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Proteasomal Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Zinc Ion Binding Regulation Of Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Cytoplasm Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Protein K48-linked Deubiquitination CD40 Receptor Complex Transferase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signaling	Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cytosol Nucleus Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Catabolic Process Cytoplasm Proteolysis Protein Polyubiquitination Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Ubiquitin Protein Ligase Binding Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein K11-linked Deubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Post-translational Protein Modification TOR Signaling Proteasome Binding Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Ubiquitin Binding Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cellular Response To Nutrient Levels Protein K6-linked Ubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Topologically Incorrect Protein Positive Regulation Of Viral Genome Replication Macromolecule Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity DNA Damage Response Ligase Inhibitor Activity Cyclic Nucleotide Binding Interleukin-5 Receptor Complex Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Polyubiquitin Modification-dependent Protein Binding
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