ODC1 and SSR1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ODC1	SSR1
Name		ornithine decarboxylase 1	signal sequence receptor subunit 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation
Pathways		Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines	SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs		Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Ewing sarcoma ( 30093639 ) Hip circumference adjusted for BMI ( 34021172 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 24509480 28869590 30718926 32499647 )
Novel Interactors		None recorded	1 novel interactors: NPC2
Interacting Genes		17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510	8 interacting genes: DKC1 EEF1A1 HSPA13 NUP54 ODC1 PTN SERPINF2 UTP14A
Entrez ID		4953	6745
HPRD ID		01324	02924
Ensembl ID		ENSG00000115758	ENSG00000124783
Uniprot IDs		B4DXF8 P11926	C9JBX5 P43307
PDB IDs		1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N	8B6L
GO Terms Enriched among Interactors		Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process	None