ODC1 and TMOD1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ODC1	TMOD1
Description		ornithine decarboxylase 1	tropomodulin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament COP9 Signalosome Membrane Myofibril Sarcomere Cortical Cytoskeleton
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity Protein Homodimerization Activity	Actin Binding Tropomyosin Binding
	Biological Process	Kidney Development Polyamine Metabolic Process Polyamine Biosynthetic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Putrescine Biosynthetic Process From Arginine, Via Ornithine Regulation Of Protein Catabolic Process	Muscle Contraction Actin Filament Organization Adult Locomotory Behavior Myofibril Assembly Pointed-end Actin Filament Capping Lens Fiber Cell Development
Pathways		Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines	Striated Muscle Contraction
Drugs		Pyridoxal phosphate Spermine Sildenafil Valproic acid Putrescine Pyridoxine phosphate N-Pyridoxyl-Glycine-5-Monophosphate L-Eflornithine N(6)-(pyridoxal phosphate)-L-lysine Geneticin Eflornithine
Diseases
GWAS			Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Intracranial aneurysm ( 30823506) Obesity-related traits ( 23251661) Thyroid cancer (Papillary, radiation-related) ( 20350937) Zinc levels ( 26025379)
Interacting Genes		17 interacting genes: BAAT CSNK2B GORASP2 HEMGN KAT5 MAP2K1 NANS OAZ1 OAZ2 RSC1A1 SSR1 STX17 TDRD7 TK1 TMOD1 TSTD2 ZNF510	16 interacting genes: APC BUB1 CDH1 CDKN2A DCC DLC1 FBXL17 FBXW7 MLH3 NEB ODC1 PIK3CA PRKAA2 TLR2 TMSB10 TPM3
Entrez ID		4953	7111
HPRD ID		01324	01838
Ensembl ID		ENSG00000115758	ENSG00000136842
Uniprot IDs		B4DXF8 P11926	P28289
PDB IDs		1D7K 2ON3 2OO0 4ZGY 5BWA 7S3F 7S3G 7U6P 7U6U 9B8M 9B8N	4PKG 4PKH 4PKI 4Z8G 4Z94 8F8T
Enriched GO Terms of Interacting Partners?		Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Viral Translational Frameshifting Polyamine Biosynthetic Process Polyamine Metabolic Process Negative Regulation Of Transmembrane Transport Golgi Organization Viral Process Amine Biosynthetic Process Biogenic Amine Biosynthetic Process	Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Regulation Of Cytoskeleton Organization Apoptotic Process Negative Regulation Of Cell Development Cell Death Programmed Cell Death Negative Regulation Of Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Communication Negative Regulation Of Supramolecular Fiber Organization Catenin Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Cytosol Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Nervous System Development Regulation Of Organelle Organization Negative Regulation Of Cell Growth Negative Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell-matrix Adhesion Lamellipodium Sister Chromatid Cohesion Regulation Of Macroautophagy Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Cellular Response To Oxygen-containing Compound Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Protein Targeting To Mitochondrion Ligase Inhibitor Activity Supramolecular Fiber Organization Triacyl Lipopeptide Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Growth Negative Regulation Of Axonogenesis Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization
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