C1R

Description		complement C1r
Image
GO Annotations	Cellular Component	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Molecular Sequestering Activity
	Biological Process	Activation Of Membrane Attack Complex Immune System Process Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Novel Interacting Genes		1 novel interacting genes: TUBGCP2
Interacting Genes		7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		715
HPRD ID		01954
Ensembl ID		ENSG00000159403
Uniprot IDs		A0A3B3ISR2 B4DPQ0 P00736
PDB IDs		1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39 9EKD 9EKE
Enriched GO Terms of Interacting Partners?		Complement Component C1 Complex Symbiont Cell Surface Complement Component C1q Complex Complement Activation, Classical Pathway Regulation Of Immune Response IgM Binding Complement Activation Positive Regulation Of Immune Response Synapse Pruning Regulation Of Immune System Process IgG Binding Blood Microparticle Activation Of Immune Response Tricarboxylic Acid Metabolic Process Positive Regulation Of Immune System Process Humoral Immune Response Gluconeogenesis Phosphatidylserine Binding Protein Maturation Hexose Biosynthetic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Protein Serine Kinase Activity (using GTP As Donor) Collagen Trimer Immune Effector Process Negative Regulation Of Complement Activation, Lectin Pathway Extracellular Matrix Response To Stress Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process Response To Other Organism Protein Localization To Chromosome Carbohydrate Biosynthetic Process Vertebrate Eye-specific Patterning
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