TLR3 and RNF216

Number of citations of the paper that reports this interaction (PMID 15107846)
62

Data Source:
HPRD (two hybrid)

		TLR3	RNF216
Gene Name		toll-like receptor 3	ring finger protein 216
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Double-stranded RNA Binding Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Microglial Cell Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Hyperosmotic Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation Male Gonad Development Detection Of Virus Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Drug Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Apoptotic Process Response To Exogenous DsRNA Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Mechanical Stimulus Cellular Response To Interferon-gamma Cellular Response To Exogenous DsRNA Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination
Pathways		TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Breast size ( 22747683)
Protein-Protein Interactions		8 interactors: CD14 CSK MAP2K6 MYD88 RNF216 TICAM1 TICAM2 TRAF6	11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6
Entrez ID		7098	54476
HPRD ID		04324	15550
Ensembl ID			ENSG00000011275
Uniprot IDs		E6Y0F1 O15455	A8K8N1 Q9NWF9
PDB IDs		1ZIW 2A0Z 3ULU 3ULV
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Regulation Of Immune System Process Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Response Positive Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Cellular Response To Lipid Cellular Response To Organic Substance Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Chemokine Production Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Cell Activation	Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity
Tagcloud ?		addressed adoptive autoimmune cytoskeletal defective deletes detects displaying drive dx5 ex immunotherapies intermediates lymphocyte marginal mobilization myd88 polyic retained spleen subsets t1d toll traced trif triggers unexpectedly zone	amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Difference) ?		addressed adoptive autoimmune cytoskeletal defective deletes detects displaying drive dx5 ex immunotherapies intermediates lymphocyte marginal mobilization myd88 polyic retained spleen subsets t1d toll traced trif triggers unexpectedly zone	amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Intersection) ?