TLR3 and MYD88

Number of citations of the paper that reports this interaction (PubMedID 12646618)
0

Data Source:
HPRD (in vitro)

		TLR3	MYD88
Description		toll like receptor 3	MYD88 innate immune signal transduction adaptor
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Signaling Receptor Binding Toll Binding Death Receptor Binding Cytokine Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity TIR Domain Binding ATP-dependent Histone Chaperone Activity
	Biological Process	MAPK Cascade Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Regulation Of Dendritic Cell Cytokine Production Defense Response Inflammatory Response Hyperosmotic Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Male Gonad Development Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Type III Interferon Production Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cellular Response To Exogenous DsRNA Cellular Response To Xenobiotic Stimulus Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Cellular Response To Virus Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Response To Molecule Of Fungal Origin Leukocyte Activation Involved In Inflammatory Response Neutrophil Activation Involved In Immune Response Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Organization Chromatin Remodeling Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Microglia Differentiation Response To Amine Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Neurogenesis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-33-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Skin Development Innate Immune Response Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Neutrophil-mediated Killing Of Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation RSV-host interactions	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		13 interacting genes: CD14 CFTR CHEK2 CSK HLA-DRA IRGM MAP2K6 MYD88 RNF10 RNF216 TICAM1 TICAM2 TRAF6	44 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF152 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		7098	4615
HPRD ID		04324	03703
Ensembl ID		ENSG00000164342	ENSG00000172936
Uniprot IDs		O15455	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 A0A494C0J8 Q99836
PDB IDs		1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0 7C76 7WV3 7WV4 7WV5 7WVE 7WVF 7WVJ 8AR1 8YHT 8YHU 9LSH 9LSI 9LSJ	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N 7BEQ 7BER 7L6W 8S78 8W8M
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Endosome Membrane Toll-like Receptor Signaling Pathway Response To Lipopolysaccharide TRIF-dependent Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Immune System Process Signaling Adaptor Activity Positive Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Immune Response Response To Lipid Endolysosomal Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lymphocyte Activation Innate Immune Response Regulation Of Cell Activation	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Positive Regulation Of Cytokine Production Regulation Of Immune Response Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Defense Response To Other Organism Positive Regulation Of Immune Response Defense Response Positive Regulation Of Gene Expression Regulation Of Cytokine Production Response To Other Organism Defense Response To Symbiont Response To External Biotic Stimulus Positive Regulation Of Immune System Process Immune System Process Immune Response Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Regulation Of Interferon-beta Production Inflammatory Response Positive Regulation Of Interleukin-8 Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Interferon-beta Production Cell Surface Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of Interferon-alpha Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-8 Production Interleukin-1-mediated Signaling Pathway
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