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TLR3
Gene Name
toll-like receptor 3
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Endolysosome Membrane
Molecular Function
Double-stranded RNA Binding
Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Biological Process
Toll-like Receptor Signaling Pathway
Microglial Cell Activation Involved In Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
Inflammatory Response
Hyperosmotic Response
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
Male Gonad Development
Detection Of Virus
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Type III Interferon Production
Cellular Response To Interferon-beta
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Drug
Positive Regulation Of NF-kappaB Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of Apoptotic Process
Response To Exogenous DsRNA
Positive Regulation Of Interferon-gamma Biosynthetic Process
Positive Regulation Of Chemokine Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interferon-alpha Biosynthetic Process
Positive Regulation Of Interferon-beta Biosynthetic Process
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Cellular Response To Mechanical Stimulus
Cellular Response To Interferon-gamma
Cellular Response To Exogenous DsRNA
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Pathways
TRAF6 mediated induction of TAK1 complex
IKK complex recruitment mediated by RIP1
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
MyD88-independent cascade
RIP-mediated NFkB activation via ZBP1
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Activated TLR4 signalling
Toll-Like Receptors Cascades
Trafficking and processing of endosomal TLR
ZBP1(DAI) mediated induction of type I IFNs
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
TRIF-mediated programmed cell death
Innate Immune System
Drugs
Diseases
GWAS
Breast size (
22747683
)
Protein-protein Interactions
8 interactors:
CD14
CSK
MAP2K6
MYD88
RNF216
TICAM1
TICAM2
TRAF6
Entrez ID
7098
HPRD ID
04324
Ensembl ID
Uniprot IDs
E6Y0F1
O15455
PDB IDs
1ZIW
2A0Z
3ULU
3ULV
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Innate Immune Response
Regulation Of Interleukin-6 Production
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Innate Immune Response
Cellular Response To Lipopolysaccharide
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Immune Response
Positive Regulation Of Immune System Process
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Interleukin-6 Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
Defense Response
Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cytokine Production
Cellular Response To Lipid
Cellular Response To Organic Substance
Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Chemokine Production
Immune System Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Regulation Of Chemokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 9 Signaling Pathway
Response To Organic Substance
Positive Regulation Of Cytokine Biosynthetic Process
Response To Other Organism
Response To Biotic Stimulus
Positive Regulation Of Cell Activation
Tagcloud
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addressed
adoptive
autoimmune
cytoskeletal
defective
deletes
detects
displaying
drive
dx5
ex
immunotherapies
intermediates
lymphocyte
marginal
mobilization
myd88
polyic
retained
spleen
subsets
t1d
toll
traced
trif
triggers
unexpectedly
zone